Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 221202..221731 Replicon chromosome
Accession NZ_CP044316
Organism Enterococcus faecium strain 15-307-1

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag CWC51_RS01095 Protein ID WP_002296560.1
Coordinates 221465..221731 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag CWC51_RS01090 Protein ID WP_002296559.1
Coordinates 221202..221465 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CWC51_RS01080 218576..220399 + 1824 WP_002294202.1 APC family permease -
CWC51_RS01085 220541..220726 - 186 WP_002296558.1 transcriptional regulator -
CWC51_RS01090 221202..221465 + 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CWC51_RS01095 221465..221731 + 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
CWC51_RS01100 221932..222420 + 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
CWC51_RS01105 222961..223632 - 672 WP_002302663.1 ABC transporter permease -
CWC51_RS01110 223629..224546 - 918 WP_002296564.1 osmoprotectant ABC transporter substrate-binding protein -
CWC51_RS01115 224543..225184 - 642 WP_002293405.1 ABC transporter permease -
CWC51_RS01120 225188..225769 - 582 Protein_223 CBS domain-containing protein -
CWC51_RS01125 225927..226331 + 405 WP_002287522.1 IS200/IS605-like element ISEfa4 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T140683 WP_002296560.1 NZ_CP044316:221465-221731 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T140683 NZ_CP059345:c3220057-3219647 [Providencia rettgeri]
GTGGTCCTGTGGAAATCTAATCTTTCCATTTCATGGAAAACACAGTTTTTTTCAACCTGTGTTCATGGGGCAGTAGGCAT
GTTTTTGCTTGTTGCACCATGGGCACCGGCTCATTCAATGATATGGTTGCCACTTCTTGCGGTTGTGGTGGCTAGTTGGG
CAAAAAGCCAAAAGAACATCAGCAAAATAAAAGGGGTTGCTGTGTTGGTTAATGGTAATAAAGTCCAATGGAAAAAGAAT
GAATGGAATATTGTGAAAGCACCTTGGTTGAGCCGCTATGGCATCTTATTGTCATTAGAAGCTTTACAAGGTAAGCAACA
AAAAATTCACCTATGGGTTGCTAAAGACTCTGTTTCTGAGGAAAGTTGGCGTAATTTGAACCAATTATTACTTCAATACC
CTGATATTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT140683 WP_002296559.1 NZ_CP044316:221202-221465 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp

>AT140683 NZ_CP059345:c3220304-3220038 [Providencia rettgeri]
ATGGATATTGAGAACAAGGCGCGAATTCATTGGGCTTGTCGCCGCGGTATGCGTGAGCTAGATATTTCAATCATGCCATT
TTTTGAGTATGAATATGATAGTCTGACAACCAATGATAAACAGGTGTTTGTCCGTTTATTGGAGTGTGCGGACCCTGATT
TATTTAACTGGTTAATGAATCACGGTCGCCCAGATGACGACGAGCTATTTCGTATGGTAAAACTGATTCAGGAAAAAAAT
AAAAATCGTGGTCCTGTGGAAATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References