Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3874897..3875492 Replicon chromosome
Accession NZ_CP044315
Organism Escherichia coli strain SJ7

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag F7D02_RS19410 Protein ID WP_000239579.1
Coordinates 3874897..3875247 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag F7D02_RS19415 Protein ID WP_001223208.1
Coordinates 3875241..3875492 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D02_RS19390 3870343..3871365 - 1023 WP_001298926.1 ABC transporter permease -
F7D02_RS19395 3871379..3872881 - 1503 WP_000205800.1 sugar ABC transporter ATP-binding protein -
F7D02_RS19400 3873021..3873977 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
F7D02_RS19405 3874287..3874817 + 531 WP_000055072.1 inorganic diphosphatase -
F7D02_RS19410 3874897..3875247 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
F7D02_RS19415 3875241..3875492 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
F7D02_RS19420 3875705..3876046 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
F7D02_RS19425 3876049..3879828 - 3780 WP_000060938.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T140676 WP_000239579.1 NZ_CP044315:c3875247-3874897 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T140676 NZ_CP059343:185232-185795 [Kocuria varians]
ATGTCGTTCCCGGTGGTTCTCGATGCATGCGTATTGATTCCCATGCCTATCGCAGATCTACTACTGCGTCTGGCAACGGC
CAAGCAATTCAGGCCGCTTTGGTCGGATGAGATTCTGAACGAGGTAGAGCGCAATCTGGTGAAGAATCTTCACAAGGACC
CGCACAGCGCTCGCAGACGTGTGAACGCCATGCGGGGTTTCTTCCCCGATGCTCTGGTCGAGAACTACGAGAGCCTCGTG
CCTGCCATGACCAATGACCCCAAGGACAGACATGTGCTGGCGGCAGCGGTCCGTTCAAGAGCCGAGCTCATCGTGACATC
CAACCAGAAGGACTTCCCGACGACCGCCCTCAAGCCCTATGACGTTGCGGTGCGGTCTCCGGATGACTTCTTACTCGACC
AGTTGGATTTGGACCCTTCAACCGTGGTCCGCATCGCCGAAGAAGTGGTGGCGGACATGCGGAATCCGACGATCACGTGG
AATGGGTACCTCGAGGGTCTCGCTCGCGCCGGCTTGCCCCTATTTGCTACGGAACTCGAAAAGCGGACCGCAGGAGTCGG
CTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT140676 WP_001223208.1 NZ_CP044315:c3875492-3875241 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT140676 NZ_CP059343:184740-185225 [Kocuria varians]
ATGACAACCGCCCCGCTGGATCGCTCAACTGTCGCACCCACCCCGGCTCATGAGGAAGAACTGAAAGCCCTCGCGGCCTT
CCTCGAGGCCGCGCCCTCAGCACAGGGCCGCGGGATCCCATATCTGGTGTCTCCGACCGGAGCCACACAGCAGATCCCCG
CTGAGGTCTACTCCCTGCTCACACACGTCGTGGACGCGCTTGCCAACAACCGCGGCGTCTCCGTGGTACCTACCAACGCG
AAGCTGACCACCCAGCAAGCTGCTGATCATCTGGGAATTTCCCGGCCGACACTGGTCAAGCTGCTGGAGCAAGGTGATAT
CCCATTCACCAAAGTCGGAAGGCACCGCAGAGTCCTGCTGACTGATCTCATTGCCTACGAAGAACGCCTCGAGAAGACAC
GCCGCGAAGGCCTCCGACAGGCAACTCACGAGGCAGCTAACCACGGCACATACTTCGACATCCCGGCAGACCCGGCCACC
CGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References