Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2522824..2523302 Replicon chromosome
Accession NZ_CP044315
Organism Escherichia coli strain SJ7

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag F7D02_RS12980 Protein ID WP_001303876.1
Coordinates 2523015..2523302 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag F7D02_RS12975 Protein ID WP_000536233.1
Coordinates 2522824..2523015 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D02_RS12940 2518204..2518974 - 771 WP_000450992.1 DUF1627 domain-containing protein -
F7D02_RS12945 2519056..2519742 - 687 WP_000788749.1 ATP-binding protein -
F7D02_RS12950 2519749..2520864 - 1116 WP_001205820.1 hypothetical protein -
F7D02_RS12955 2520943..2521398 + 456 WP_000273724.1 hypothetical protein -
F7D02_RS12960 2521605..2522030 - 426 WP_000693855.1 Rha family transcriptional regulator -
F7D02_RS12965 2522014..2522286 - 273 WP_000887453.1 helix-turn-helix domain-containing protein -
F7D02_RS12970 2522395..2522796 + 402 WP_000986592.1 helix-turn-helix domain-containing protein -
F7D02_RS12975 2522824..2523015 + 192 WP_000536233.1 hypothetical protein Antitoxin
F7D02_RS12980 2523015..2523302 + 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7D02_RS12985 2523579..2523734 + 156 WP_000379575.1 DUF1391 family protein -
F7D02_RS12990 2523876..2524265 + 390 WP_000394511.1 hypothetical protein -
F7D02_RS12995 2524452..2524637 - 186 WP_001133046.1 hypothetical protein -
F7D02_RS13000 2525211..2525399 + 189 WP_000413705.1 cell division inhibition protein DicB -
F7D02_RS13005 2525396..2525587 + 192 WP_001098307.1 DUF1482 family protein -
F7D02_RS13010 2525681..2528152 + 2472 WP_000034468.1 exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T140671 WP_001303876.1 NZ_CP044315:2523015-2523302 [Escherichia coli]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T140671 NZ_CP059331:880489-880740 [Mannheimia haemolytica]
ATGTACCATATTGAACGCACTGAAATTTTCGACCAATGGCTTGAAAATTTAAAAGATCCACTTGCTGTGGTGACCATTGC
AAGACGTATTGAACGTGCCGAAAGCGGAAATTTTGGCGATACCAAATATATCGCAGAAGGAATTTCCGAAATGAGATTAA
ACGTCAGCAAAGGTTATCGCCTTTACTATGCACAAAAAGGTAGCATTATTTATATACTACTAAATGGAGGATATAAAGGC
ACGCCAAGCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT140671 WP_000536233.1 NZ_CP044315:2522824-2523015 [Escherichia coli]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT140671 NZ_CP059331:880856-881131 [Mannheimia haemolytica]
ATGGGTATCACCGAATTTGATGCCGCCGAATACCTCACCAATGACGAGCTAATCGCCCTTTATTTGGCGGAAACATTGAA
AGACGGCACGGACGAGGAGTTTATTCAGGCATTGAATACCGTGGCACGAGCGAAAGGAATGAATGAGTTAGCGAAAAAAG
CAGGGATCGGGCGTGAAAGTTTGTATCAAAGCCTTTCCAGCAGTAAGCCCCGTTTTGAGACTATCCGCAAAATTATTAGC
GCATTAAATTTGGAGTTGTCGGTCGTTAAGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References