Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 344425..344898 Replicon chromosome
Accession NZ_CP044313
Organism Escherichia coli strain RM11911

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag F7D04_RS01840 Protein ID WP_032214969.1
Coordinates 344425..344706 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag F7D04_RS01845 Protein ID WP_032214970.1
Coordinates 344710..344898 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D04_RS01810 339459..341912 - 2454 WP_151077958.1 exonuclease -
F7D04_RS01815 341990..342193 - 204 WP_050940247.1 DUF1482 family protein -
F7D04_RS01820 342190..342378 - 189 WP_032215066.1 cell division inhibition protein DicB -
F7D04_RS01825 343080..343526 + 447 WP_000373330.1 hypothetical protein -
F7D04_RS01830 343605..343979 - 375 WP_001345627.1 hypothetical protein -
F7D04_RS01835 343991..344143 - 153 WP_151077960.1 DUF1391 family protein -
F7D04_RS01840 344425..344706 - 282 WP_032214969.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7D04_RS01845 344710..344898 - 189 WP_032214970.1 hypothetical protein Antitoxin
F7D04_RS01850 344928..345326 - 399 WP_032214971.1 helix-turn-helix domain-containing protein -
F7D04_RS01855 345443..345721 + 279 WP_032214972.1 helix-turn-helix domain-containing protein -
F7D04_RS01860 345705..346226 + 522 WP_033559708.1 hypothetical protein -
F7D04_RS01865 346207..347172 + 966 WP_033559707.1 phage O protein family -
F7D04_RS01870 347179..347925 + 747 WP_033559706.1 ATP-binding protein -
F7D04_RS01875 347940..348332 + 393 WP_151077962.1 DUF977 family protein -
F7D04_RS01880 348329..348625 + 297 WP_074154310.1 DUF4406 domain-containing protein -
F7D04_RS01885 348818..349129 + 312 WP_097418813.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 333903..384039 50136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10742.45 Da        Isoelectric Point: 6.7152

>T140605 WP_032214969.1 NZ_CP044313:c344706-344425 [Escherichia coli]
MLPVLWLESADADLDDITSYIARFDIDAAERLWKRLRACVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVAASSIE
IVSIVHARRQFPR

Download         Length: 282 bp

>T140605 NZ_CP059323:32289-32558 [Mannheimia haemolytica]
ATGCGAGAGATTGAGTATAGTAATGCTTTTAAACGTGACTATAAAAAATGTGCGGTTGAGTCTTTATCCTCTTCATTAAT
TGAGGCGTTGTATTTTCTGATTAATGACAAGCCATTACCTGAGAAATACTGCGATCACGCTTTAACCGGCGAATGGAAAG
GTTTTAGGGATTGCCATATCCAACCTGATTTGGTTCTTATCTATCGAAAAGTGGAAGATGATAAGCTAGAGCTGCTGCGA
ATTGGCAGCCACTCTCATTTATTTGGCTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7232.20 Da        Isoelectric Point: 7.0135

>AT140605 WP_032214970.1 NZ_CP044313:c344898-344710 [Escherichia coli]
MNTALSPMVSEFETIEQENSYNEWLRAKVAASLADPRPAIPHDEVERRMAERFAKIRKERSK

Download         Length: 189 bp

>AT140605 NZ_CP059323:32036-32302 [Mannheimia haemolytica]
ATGGCAAATAGTGCATTAGTAAGCGTAAGAATCAGCCCTGAAATTAAAGAGCAAGCAAGTGAGGTGTTAGCCGGTATCGG
CTTGACTGTCTCTGATGTGATGCGAATGACATTAGCGAAAATCGCAACAGAAAAACGTTTTCAGTTTGATTATCAGCCTA
ATTTTGAGACAGCAGAAGTATTAAGGGCTGTTAAGAATGGCGAGGAAAAGCTACATTCAGCAAATAGTATTGCGGATTTA
ATGGAGCAACTCAATGCGAGAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References