Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3949209..3949863 Replicon chromosome
Accession NZ_CP044312
Organism Escherichia coli strain RM13745

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag F7D05_RS19400 Protein ID WP_050938831.1
Coordinates 3949209..3949616 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F7D05_RS19405 Protein ID WP_000354046.1
Coordinates 3949597..3949863 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D05_RS19380 3945166..3946899 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
F7D05_RS19385 3946905..3947615 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F7D05_RS19390 3947640..3948536 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F7D05_RS19395 3948648..3949169 + 522 WP_001055874.1 flavodoxin FldB -
F7D05_RS19400 3949209..3949616 - 408 WP_050938831.1 protein YgfX Toxin
F7D05_RS19405 3949597..3949863 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F7D05_RS19410 3950106..3951086 + 981 WP_050938832.1 tRNA-modifying protein YgfZ -
F7D05_RS19415 3951282..3951941 - 660 WP_000250274.1 hemolysin III family protein -
F7D05_RS19420 3952105..3952416 - 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
F7D05_RS19425 3952461..3953894 + 1434 WP_050938838.1 6-phospho-beta-glucosidase BglA -
F7D05_RS19430 3953956..3954698 - 743 Protein_3801 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16071.98 Da        Isoelectric Point: 11.5202

>T140600 WP_050938831.1 NZ_CP044312:c3949616-3949209 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMHWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T140600 NZ_CP059319:c372840-372505 [Rhizorhabdus wittichii]
GTGACCTTTGACCGGTTCGACACGGTCGTCGTGCCCTTTCCCTTCACCGACCGGCGCACGACCAAGCGGCGTCCCGCGCT
GATGCTCAGCGACCGGGCCTTTGGTGAGGCGACCGACAATGCGCTGCTCGCGATGATAACCTCCGCCGAACAATCCGACT
GGCCGGGCGACACCGCCCTCAGCGATCGGGAGCGCGCCGGCCTGCCCAAGCCCTGCAAGGTCCGGATGAAGCTGTTCACC
CTCGACCATCGGCTGATCGAGCGACGGATCGGCACATTGTCGCAAGCCGACCGCGACGCGGTCGTTCGCGCGCTCCGAAC
GGTGGTCGGGCTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140600 WP_000354046.1 NZ_CP044312:c3949863-3949597 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140600 NZ_CP059319:c373054-372830 [Rhizorhabdus wittichii]
ATGGACGTCAGCAAGCTCACGGCGAAGAACCAGGTGACGATCCCGGCCGACGTCCGGCAGCAGCTCGGCGTCAAATCGGG
CGATCATGTCGCCTTCGAGGTCGAAGACGGCAAGGTGATCGTGCGCAAGGCTCGCGCGATCGATTGGGCCTGGACGGCGA
CGGTCGGATCGACCTTGAGCGAATGGTCGAGCGACGCCGACGAAGAGGCCTTCCGTGACCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References