Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3332705..3333540 | Replicon | chromosome |
| Accession | NZ_CP044311 | ||
| Organism | Escherichia coli strain RM13752 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | - |
| Locus tag | F7D06_RS16450 | Protein ID | WP_050938921.1 |
| Coordinates | 3333163..3333540 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A0H0IVG5 |
| Locus tag | F7D06_RS16445 | Protein ID | WP_001339471.1 |
| Coordinates | 3332705..3333073 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F7D06_RS16415 | 3329541..3329996 | + | 456 | WP_000581504.1 | hypothetical protein | - |
| F7D06_RS16420 | 3330075..3330308 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| F7D06_RS16425 | 3330408..3331226 | + | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| F7D06_RS16430 | 3331281..3331766 | + | 486 | WP_050938918.1 | antirestriction protein | - |
| F7D06_RS16435 | 3331782..3332258 | + | 477 | WP_001186727.1 | RadC family protein | - |
| F7D06_RS16440 | 3332321..3332542 | + | 222 | WP_050938919.1 | DUF987 domain-containing protein | - |
| F7D06_RS16445 | 3332705..3333073 | + | 369 | WP_001339471.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| F7D06_RS16450 | 3333163..3333540 | + | 378 | WP_050938921.1 | TA system toxin CbtA family protein | Toxin |
| F7D06_RS16455 | 3333537..3334025 | + | 489 | WP_000761721.1 | hypothetical protein | - |
| F7D06_RS16460 | 3334037..3334234 | + | 198 | WP_000839281.1 | DUF957 domain-containing protein | - |
| F7D06_RS16465 | 3334331..3334903 | + | 573 | WP_001290246.1 | DUF4942 domain-containing protein | - |
| F7D06_RS16470 | 3335184..3335720 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| F7D06_RS16475 | 3335722..3336900 | - | 1179 | WP_000094974.1 | type II secretion system protein GspL | - |
| F7D06_RS16480 | 3336897..3337874 | - | 978 | WP_000633238.1 | type II secretion system minor pseudopilin GspK | - |
| F7D06_RS16485 | 3337877..3338476 | - | 600 | WP_064760790.1 | type II secretion system minor pseudopilin GspJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspE / gspD / gspC / rfaE | 3288701..3473337 | 184636 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14209.18 Da Isoelectric Point: 7.7761
>T140570 WP_050938921.1 NZ_CP044311:3333163-3333540 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR
Download Length: 378 bp
>T140570 NZ_CP059311:c122669-122199 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13517.22 Da Isoelectric Point: 6.4789
>AT140570 WP_001339471.1 NZ_CP044311:3332705-3333073 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK
Download Length: 369 bp
>AT140570 NZ_CP059311:c123109-122666 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|