Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3197240..3197894 Replicon chromosome
Accession NZ_CP044311
Organism Escherichia coli strain RM13752

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag F7D06_RS15800 Protein ID WP_050938831.1
Coordinates 3197240..3197647 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F7D06_RS15805 Protein ID WP_000354046.1
Coordinates 3197628..3197894 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7D06_RS15780 3193197..3194930 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
F7D06_RS15785 3194936..3195646 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F7D06_RS15790 3195671..3196567 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F7D06_RS15795 3196679..3197200 + 522 WP_001055874.1 flavodoxin FldB -
F7D06_RS15800 3197240..3197647 - 408 WP_050938831.1 protein YgfX Toxin
F7D06_RS15805 3197628..3197894 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F7D06_RS15810 3198137..3199117 + 981 WP_050938832.1 tRNA-modifying protein YgfZ -
F7D06_RS15815 3199313..3199972 - 660 WP_000250274.1 hemolysin III family protein -
F7D06_RS15820 3200136..3200447 - 312 WP_001514524.1 N(4)-acetylcytidine aminohydrolase -
F7D06_RS15825 3200492..3201925 + 1434 WP_050938838.1 6-phospho-beta-glucosidase BglA -
F7D06_RS15830 3201987..3202729 - 743 Protein_3093 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16071.98 Da        Isoelectric Point: 11.5202

>T140569 WP_050938831.1 NZ_CP044311:c3197647-3197240 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMHWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T140569 NZ_CP059311:37931-38413 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140569 WP_000354046.1 NZ_CP044311:c3197894-3197628 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140569 NZ_CP059311:37662-37940 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References