Detailed information of TA system TA140508

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 20203..21079
• Replicon: plasmid pCA639-2
• Accession: NZ_CP044263
• Organism: Campylobacter armoricus strain CA639

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: F6X58_RS08775
• Protein ID: WP_139454154.1
• Coordinates: 20203..20841 (-)
• Length: 213 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: -
• Locus tag: F6X58_RS08780
• Protein ID: WP_057039917.1
• Coordinates: 20825..21079 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6X58_RS08740	15976..16182	-	207	WP_139454149.1	hypothetical protein	-
F6X58_RS08745	16273..17358	-	1086	WP_126267761.1	site-specific DNA-methyltransferase	-
F6X58_RS08750	17358..18185	-	828	WP_126267760.1	type II restriction endonuclease	-
F6X58_RS08755	18277..18501	-	225	WP_139454150.1	hypothetical protein	-
F6X58_RS08760	18504..19190	-	687	WP_139454151.1	AAA family ATPase	-
F6X58_RS08765	19271..19666	-	396	WP_139454152.1	conjugal transfer protein TraM	-
F6X58_RS08770	19731..20198	-	468	WP_139454153.1	signal peptidase I	-
F6X58_RS08775	20203..20841	-	639	WP_139454154.1	Fic family protein	Toxin
F6X58_RS08780	20825..21079	-	255	WP_057039917.1	hypothetical protein	Antitoxin
F6X58_RS08785	21171..21890	-	720	WP_139454155.1	conjugal transfer protein TraL	-
F6X58_RS08790	21901..23724	-	1824	WP_139454156.1	type IV secretory system conjugative DNA transfer family protein	-
F6X58_RS08795	23721..25931	-	2211	WP_139454157.1	DUF1738 domain-containing protein	-
F6X58_RS08995	25936..26076	-	141	WP_167507515.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..28140	28140

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (50-154)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 213 a.a.
• Molecular weight: 24456.98 Da
• Isoelectric Point: 9.6243

>T140508 WP_139454154.1 NZ_CP044263:c20841-20203 [Campylobacter armoricus]
MKESNEELFKRLITDNKLGIKDEKLFDKASRFYTGLRERELTLNPIKGNFDYQHLKNIHKHIFQDVFYWAGKDRMEVGLS
SFMSKGDSLFCSAEYIPGEAKKIFDELAKNNYLKNSKDLNHFAKDLANFISDLNALHPFREGNGRTQRIFLNELAKNAGY
KLDLNLISKEKMIEASIEAMGGRNGKLEAVIKTNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 639 bp

>T140508 NZ_CP059288:c583368-582922 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9812.20 Da
• Isoelectric Point: 4.7225

>AT140508 WP_057039917.1 NZ_CP044263:c21079-20825 [Campylobacter armoricus]
MQKQYPEVHSLEESLAILKKYKDDVNKEDYEGIKSVISNHAIESIYMNELDIIAMIKQSALKLSADEIIAEYKEKGFVEY
ERKQ

Nucleotide

• Length: 255 bp

>AT140508 NZ_CP059288:c583703-583368 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA