Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 54..634 Replicon plasmid p3
Accession NZ_CP044260
Organism Klebsiella pneumoniae strain KP65

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag F6W81_RS28290 Protein ID WP_071177730.1
Coordinates 320..634 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag F6W81_RS28285 Protein ID WP_000093040.1
Coordinates 54..332 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W81_RS28285 54..332 + 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
F6W81_RS28290 320..634 + 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6W81_RS28295 798..1226 + 429 WP_001140599.1 hypothetical protein -
F6W81_RS28300 1252..1431 + 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
F6W81_RS28305 1458..1988 - 531 WP_071177729.1 hypothetical protein -
F6W81_RS28310 1995..2726 - 732 WP_071177728.1 replication-relaxation family protein -
F6W81_RS28315 2726..4690 - 1965 WP_071177727.1 TraM recognition domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T140507 WP_071177730.1 NZ_CP044260:320-634 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

>T140507 NZ_CP059288:164834-164941 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT140507 WP_000093040.1 NZ_CP044260:54-332 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp

>AT140507 NZ_CP059288:c164786-164720 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References