Detailed information of TA system TA140507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 54..634
• Replicon: plasmid p3
• Accession: NZ_CP044260
• Organism: Klebsiella pneumoniae strain KP65

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A8J3DTL7
• Locus tag: F6W81_RS28290
• Protein ID: WP_071177730.1
• Coordinates: 320..634 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2X1PRM1
• Locus tag: F6W81_RS28285
• Protein ID: WP_000093040.1
• Coordinates: 54..332 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6W81_RS28285	54..332	+	279	WP_000093040.1	CopG family ribbon-helix-helix protein	Antitoxin
F6W81_RS28290	320..634	+	315	WP_071177730.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F6W81_RS28295	798..1226	+	429	WP_001140599.1	hypothetical protein	-
F6W81_RS28300	1252..1431	+	180	WP_000165970.1	Rop family plasmid primer RNA-binding protein	-
F6W81_RS28305	1458..1988	-	531	WP_071177729.1	hypothetical protein	-
F6W81_RS28310	1995..2726	-	732	WP_071177728.1	replication-relaxation family protein	-
F6W81_RS28315	2726..4690	-	1965	WP_071177727.1	TraM recognition domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..10060	10060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-96)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11805.73 Da
• Isoelectric Point: 9.8324

>T140507 WP_071177730.1 NZ_CP044260:320-634 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Nucleotide

• Length: 315 bp

>T140507 NZ_CP059288:164834-164941 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10709.73 Da
• Isoelectric Point: 4.7561

>AT140507 WP_000093040.1 NZ_CP044260:54-332 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Nucleotide

• Length: 279 bp

>AT140507 NZ_CP059288:c164786-164720 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A2X1PRM1