Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5033644..5035325 Replicon chromosome
Accession NZ_CP044258
Organism Klebsiella pneumoniae strain KP65

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag F6W81_RS25180 Protein ID WP_002885155.1
Coordinates 5033644..5034561 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag F6W81_RS25185 Protein ID WP_004151732.1
Coordinates 5034567..5035325 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W81_RS25160 5028950..5030470 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
F6W81_RS25165 5030467..5031465 + 999 WP_002885172.1 ribose ABC transporter permease -
F6W81_RS25170 5031496..5032437 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
F6W81_RS25175 5032512..5033519 + 1008 WP_004151731.1 carbohydrate kinase family protein -
F6W81_RS25180 5033644..5034561 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
F6W81_RS25185 5034567..5035325 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
F6W81_RS25190 5035411..5036139 - 729 WP_002885152.1 response regulator transcription factor -
F6W81_RS25195 5036412..5038559 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
F6W81_RS25200 5038789..5039475 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T140498 WP_002885155.1 NZ_CP044258:c5034561-5033644 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T140498 NZ_CP059283:2617802-2617909 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT140498 WP_004151732.1 NZ_CP044258:c5035325-5034567 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT140498 NZ_CP059283:c2617755-2617689 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References