Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4876708..4877224 Replicon chromosome
Accession NZ_CP044258
Organism Klebsiella pneumoniae strain KP65

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag F6W81_RS24380 Protein ID WP_002886902.1
Coordinates 4876708..4876992 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag F6W81_RS24385 Protein ID WP_002886901.1
Coordinates 4876982..4877224 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6W81_RS24360 4872192..4872500 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
F6W81_RS28890 4872585..4872758 + 174 WP_002886906.1 hypothetical protein -
F6W81_RS24365 4872761..4873504 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
F6W81_RS24370 4873861..4875999 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
F6W81_RS24375 4876240..4876704 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F6W81_RS24380 4876708..4876992 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6W81_RS24385 4876982..4877224 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F6W81_RS24390 4877302..4879212 - 1911 WP_004152270.1 BglG family transcription antiterminator -
F6W81_RS24395 4879235..4880389 - 1155 WP_002886900.1 lactonase family protein -
F6W81_RS24400 4880455..4881195 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T140497 WP_002886902.1 NZ_CP044258:c4876992-4876708 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T140497 NZ_CP059283:2617267-2617374 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT140497 WP_002886901.1 NZ_CP044258:c4877224-4876982 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT140497 NZ_CP059283:c2617220-2617154 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References