Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT-HigA
Location 4070084..4070757 Replicon chromosome
Accession NZ_CP044222
Organism Nitrincola sp. KXZD1103

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag F5I99_RS18860 Protein ID WP_151058735.1
Coordinates 4070084..4070347 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag F5I99_RS18865 Protein ID WP_023012140.1
Coordinates 4070464..4070757 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5I99_RS18840 4065294..4067348 - 2055 WP_191905900.1 marine proteobacterial sortase target protein -
F5I99_RS18845 4067578..4068246 + 669 WP_151058729.1 two-component system response regulator CreB -
F5I99_RS18850 4068243..4069688 + 1446 WP_151058731.1 two-component system sensor histidine kinase CreC -
F5I99_RS18855 4069825..4070094 - 270 WP_151058733.1 CopG family transcriptional regulator -
F5I99_RS18860 4070084..4070347 - 264 WP_151058735.1 BrnT family toxin Toxin
F5I99_RS18865 4070464..4070757 - 294 WP_023012140.1 HigA family addiction module antidote protein Antitoxin
F5I99_RS18870 4071038..4071259 + 222 WP_151058737.1 hypothetical protein -
F5I99_RS18875 4071252..4071542 + 291 WP_151058739.1 type II toxin-antitoxin system RelE/ParE family toxin -
F5I99_RS18880 4071689..4072732 + 1044 WP_151058741.1 IS110 family transposase -
F5I99_RS19490 4072755..4072895 + 141 WP_191905901.1 hypothetical protein -
F5I99_RS18885 4073286..4073771 - 486 WP_151058743.1 GNAT family N-acetyltransferase -
F5I99_RS18890 4073902..4074270 - 369 WP_151058745.1 DUF3703 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4071689..4072732 1043


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-66)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10386.76 Da        Isoelectric Point: 6.8815

>T140472 WP_151058735.1 NZ_CP044222:c4070347-4070084 [Nitrincola sp. KXZD1103]
MNIFEFDDEKSQANRHKHGIDFHDAQVLWEDQDLLEVRAKSSDEPRYLVIGLIGMKHWSAVITYRGEKIRLISVRRSRKR
EVELYES

Download         Length: 264 bp

>T140472 NZ_CP059281:1641401-1641715 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10770.33 Da        Isoelectric Point: 6.2137

>AT140472 WP_023012140.1 NZ_CP044222:c4070757-4070464 [Nitrincola sp. KXZD1103]
MTMHNPPHPGEFIREVYLEPFGISSRQLASSLGVSPSTLSRLLKGDSGISPEMSLRLSKVLGRTPESWLAMQDMYDLWVA
RGTVNLDGIHRLDFEAA

Download         Length: 294 bp

>AT140472 NZ_CP059281:1641165-1641398 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References