Detailed information of TA system TA140470

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 3119692..3120267
• Replicon: chromosome
• Accession: NZ_CP044222
• Organism: Nitrincola sp. KXZD1103

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: F5I99_RS14345
• Protein ID: WP_151057154.1
• Coordinates: 3119692..3119808 (+)
• Length: 39 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: F5I99_RS14350
• Protein ID: WP_151057157.1
• Coordinates: 3119863..3120267 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5I99_RS14320	3114772..3115566	+	795	WP_151057144.1	carbohydrate ABC transporter permease	-
F5I99_RS14325	3115578..3115850	+	273	WP_151057146.1	DUF2160 domain-containing protein	-
F5I99_RS14330	3115908..3117635	+	1728	WP_151057148.1	ABC transporter substrate-binding protein	-
F5I99_RS14335	3117718..3118623	-	906	WP_151057150.1	U32 family peptidase	-
F5I99_RS14340	3118633..3119628	-	996	WP_151057152.1	U32 family peptidase	-
F5I99_RS14345	3119692..3119808	+	117	WP_151057154.1	type II toxin-antitoxin system HicA family toxin	Toxin
F5I99_RS14350	3119863..3120267	+	405	WP_151057157.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F5I99_RS14355	3120439..3121869	-	1431	WP_151057159.1	hypothetical protein	-
F5I99_RS14360	3121875..3122729	-	855	WP_151057161.1	hypothetical protein	-
F5I99_RS14365	3122789..3124072	-	1284	WP_151057163.1	DUF4123 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (12-37)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4213.26 Da
• Isoelectric Point: 11.4234

>T140470 WP_151057154.1 NZ_CP044222:3119692-3119808 [Nitrincola sp. KXZD1103]
MIRLIQVMVCKGKVTLPHPKKDLPTKTVASILKQAGLR

Nucleotide

• Length: 117 bp

>T140470 NZ_CP059281:c1492517-1492260 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14608.57 Da
• Isoelectric Point: 4.2332

>AT140470 WP_151057157.1 NZ_CP044222:3119863-3120267 [Nitrincola sp. KXZD1103]
MLYPVAIHHEKDSAYGVIVPDIPSCYSAGDTMEDAISNVVEAIDLHLESLVEEGGDIPQASSLEALIANEEFSGGVWLLV
DVDITKYLGNADRLNITLPHLLITKIDRAVNENKLFKSRSQFLAEASLRLLASS

Nucleotide

• Length: 405 bp

>AT140470 NZ_CP059281:c1492248-1491697 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA