Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3119692..3120267 Replicon chromosome
Accession NZ_CP044222
Organism Nitrincola sp. KXZD1103

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F5I99_RS14345 Protein ID WP_151057154.1
Coordinates 3119692..3119808 (+) Length 39 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F5I99_RS14350 Protein ID WP_151057157.1
Coordinates 3119863..3120267 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5I99_RS14320 3114772..3115566 + 795 WP_151057144.1 carbohydrate ABC transporter permease -
F5I99_RS14325 3115578..3115850 + 273 WP_151057146.1 DUF2160 domain-containing protein -
F5I99_RS14330 3115908..3117635 + 1728 WP_151057148.1 ABC transporter substrate-binding protein -
F5I99_RS14335 3117718..3118623 - 906 WP_151057150.1 U32 family peptidase -
F5I99_RS14340 3118633..3119628 - 996 WP_151057152.1 U32 family peptidase -
F5I99_RS14345 3119692..3119808 + 117 WP_151057154.1 type II toxin-antitoxin system HicA family toxin Toxin
F5I99_RS14350 3119863..3120267 + 405 WP_151057157.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F5I99_RS14355 3120439..3121869 - 1431 WP_151057159.1 hypothetical protein -
F5I99_RS14360 3121875..3122729 - 855 WP_151057161.1 hypothetical protein -
F5I99_RS14365 3122789..3124072 - 1284 WP_151057163.1 DUF4123 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(12-37)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4213.26 Da        Isoelectric Point: 11.4234

>T140470 WP_151057154.1 NZ_CP044222:3119692-3119808 [Nitrincola sp. KXZD1103]
MIRLIQVMVCKGKVTLPHPKKDLPTKTVASILKQAGLR

Download         Length: 117 bp

>T140470 NZ_CP059281:c1492517-1492260 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14608.57 Da        Isoelectric Point: 4.2332

>AT140470 WP_151057157.1 NZ_CP044222:3119863-3120267 [Nitrincola sp. KXZD1103]
MLYPVAIHHEKDSAYGVIVPDIPSCYSAGDTMEDAISNVVEAIDLHLESLVEEGGDIPQASSLEALIANEEFSGGVWLLV
DVDITKYLGNADRLNITLPHLLITKIDRAVNENKLFKSRSQFLAEASLRLLASS

Download         Length: 405 bp

>AT140470 NZ_CP059281:c1492248-1491697 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References