Detailed information of TA system TA140468

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2238728..2239253
• Replicon: chromosome
• Accession: NZ_CP044222
• Organism: Nitrincola sp. KXZD1103

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F5I99_RS10320
• Protein ID: WP_151055728.1
• Coordinates: 2238969..2239253 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F5I99_RS10315
• Protein ID: WP_151055726.1
• Coordinates: 2238728..2238979 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5I99_RS10300	2234584..2237073	+	2490	WP_151059094.1	ATP-dependent helicase HrpB	-
F5I99_RS10305	2237405..2237905	+	501	WP_151055722.1	GNAT family N-acetyltransferase	-
F5I99_RS10310	2237991..2238554	+	564	WP_151055724.1	hypothetical protein	-
F5I99_RS10315	2238728..2238979	+	252	WP_151055726.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
F5I99_RS10320	2238969..2239253	+	285	WP_151055728.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F5I99_RS10325	2239341..2239607	+	267	WP_191905833.1	hypothetical protein	-
F5I99_RS10330	2239715..2240032	+	318	WP_151055732.1	hypothetical protein	-
F5I99_RS10335	2240113..2240478	+	366	WP_151055734.1	hypothetical protein	-
F5I99_RS10340	2240695..2241840	+	1146	WP_151055736.1	hypothetical protein	-
F5I99_RS10345	2241851..2242354	+	504	WP_151055738.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2233031..2244639	11608
	-	inside	Integron	-	-	2237991..2240478	2487

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-75)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10941.90 Da
• Isoelectric Point: 10.5226

>T140468 WP_151055728.1 NZ_CP044222:2238969-2239253 [Nitrincola sp. KXZD1103]
MTYKLRFLPAALKEWEKLAAPIRSQFKKKLAERLENPRVPADKLSGYESVYKIKLRSAGYRLAYEVVDDELFVYVLAVGK
REKGKVYSSLKKRT

Nucleotide

• Length: 285 bp

>T140468 NZ_CP059281:1252591-1252764 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9163.40 Da
• Isoelectric Point: 4.1541

>AT140468 WP_151055726.1 NZ_CP044222:2238728-2238979 [Nitrincola sp. KXZD1103]
MRQVLADFSVSISELKKNPSALLTQASGSPIAVLNHNKPAAYLIPAETYEALMDMLEDYELAQLVEERRGDKDQAITVSL
DDL

Nucleotide

• Length: 252 bp

>AT140468 NZ_CP059281:1252267-1252563 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG