Detailed information of TA system TA140465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1600413..1601215
• Replicon: chromosome
• Accession: NZ_CP044222
• Organism: Nitrincola sp. KXZD1103

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: F5I99_RS07260
• Protein ID: WP_151054537.1
• Coordinates: 1600413..1600940 (-)
• Length: 176 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: -
• Locus tag: F5I99_RS07265
• Protein ID: WP_151054539.1
• Coordinates: 1600937..1601215 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5I99_RS07235	1595497..1595667	+	171	WP_151054528.1	RES family NAD+ phosphorylase	-
F5I99_RS07240	1595863..1597458	+	1596	WP_151054530.1	diguanylate cyclase	-
F5I99_RS07245	1597538..1598854	-	1317	WP_151054532.1	type II toxin-antitoxin system HipA family toxin	-
F5I99_RS07250	1598848..1599171	-	324	WP_151054534.1	helix-turn-helix domain-containing protein	-
F5I99_RS07255	1599378..1600178	-	801	WP_151054536.1	transglutaminase family protein	-
F5I99_RS07260	1600413..1600940	-	528	WP_151054537.1	GNAT family N-acetyltransferase	Toxin
F5I99_RS07265	1600937..1601215	-	279	WP_151054539.1	DUF1778 domain-containing protein	Antitoxin
F5I99_RS07270	1601356..1602903	-	1548	WP_151054541.1	plasmid pRiA4b ORF-3 family protein	-
F5I99_RS07275	1602939..1603475	-	537	WP_151054543.1	GNAT family N-acetyltransferase	-
F5I99_RS07280	1603466..1603732	-	267	WP_151054545.1	DUF1778 domain-containing protein	-
F5I99_RS07285	1603855..1604406	-	552	WP_151054547.1	pyridoxamine 5'-phosphate oxidase family protein	-
F5I99_RS07290	1604792..1605889	-	1098	WP_151054549.1	tyrosine-type recombinase/integrase	-
F5I99_RS07295	1605867..1606088	-	222	WP_151054551.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (3-85)

Sequences

Toxin

Protein

• Length: 176 a.a.
• Molecular weight: 19094.14 Da
• Isoelectric Point: 9.3381

>T140465 WP_151054537.1 NZ_CP044222:c1600940-1600413 [Nitrincola sp. KXZD1103]
MMLPAWYEEPIGKSHDRSMFDCGDAALNQFLRLHARQSHEKGAAKTYLAIADEVGKTVMGYYTLSPASIAYERTPEVIKR
GLARHEVPVFRLGRLAVDVSRQGQGLGGQLLLSAGRRCLLVAMQAGGVALLIDAKNERVANWYESYGAIPLLDAPLSLIL
SFRTIHTALTAAGKL

Nucleotide

• Length: 528 bp

>T140465 NZ_CP059281:c478254-478147 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10182.90 Da
• Isoelectric Point: 7.2047

>AT140465 WP_151054539.1 NZ_CP044222:c1601215-1600937 [Nitrincola sp. KXZD1103]
MPQIPVGTNERVSLRIASEEKLLLMRAAALQHTNLTEFVISNVVSVAQKIIDEHERLSLTERDSLRMLALLDNPPAPNDK
LMAAALSLPKRA

Nucleotide

• Length: 279 bp

>AT140465 NZ_CP059281:478311-478368 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT