Detailed information of TA system TA140464

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1989462..1990048
• Replicon: chromosome
• Accession: NZ_CP044221
• Organism: Streptococcus mutans strain NCH105

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: F5989_RS10000
• Protein ID: WP_002289644.1
• Coordinates: 1989462..1989653 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0A8KA30
• Locus tag: F5989_RS10005
• Protein ID: WP_002265422.1
• Coordinates: 1989671..1990048 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F5989_RS09985	1987506..1988372	+	867	WP_002277049.1	type II CRISPR-associated endonuclease Cas1	-
F5989_RS09990	1988369..1988713	+	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
F5989_RS09995	1988703..1989365	+	663	WP_002289642.1	type II-A CRISPR-associated protein Csn2	-
F5989_RS10000	1989462..1989653	+	192	WP_002289644.1	type II toxin-antitoxin system HicA family toxin	Toxin
F5989_RS10005	1989671..1990048	+	378	WP_002265422.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F5989_RS10010	1991377..1992270	-	894	WP_002270555.1	XRE family transcriptional regulator	-
F5989_RS10015	1992594..1992878	+	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-
F5989_RS10020	1993041..1994792	+	1752	WP_002289758.1	LPXTG cell wall anchor domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7161.56 Da
• Isoelectric Point: 10.6223

>T140464 WP_002289644.1 NZ_CP044221:1989462-1989653 [Streptococcus mutans]
MPLIGKELAKLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T140464 NZ_CP059281:c375743-375216 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14335.32 Da
• Isoelectric Point: 4.5628

>AT140464 WP_002265422.1 NZ_CP044221:1989671-1990048 [Streptococcus mutans]
MLKTYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Nucleotide

• Length: 378 bp

>AT140464 NZ_CP059281:c376016-375750 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0A8KA30