Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) SmuAT/-
Location 1150831..1151792 Replicon chromosome
Accession NZ_CP044221
Organism Streptococcus mutans strain NCH105

Toxin (Protein)


Gene name smuT Uniprot ID -
Locus tag F5989_RS05735 Protein ID WP_002264864.1
Coordinates 1151277..1151792 (-) Length 172 a.a.

Antitoxin (Protein)


Gene name smuA Uniprot ID -
Locus tag F5989_RS05730 Protein ID WP_002289426.1
Coordinates 1150831..1151277 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F5989_RS05695 1146956..1147324 - 369 Protein_1073 transposase family protein -
F5989_RS05700 1147489..1148280 + 792 WP_002289431.1 nucleotidyltransferase domain-containing protein -
F5989_RS05705 1148485..1148817 - 333 WP_002289429.1 type II toxin-antitoxin system PemK/MazF family toxin -
F5989_RS05710 1148811..1149056 - 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
F5989_RS05715 1149378..1149770 - 393 WP_002262992.1 30S ribosomal protein S9 -
F5989_RS05720 1149795..1150241 - 447 WP_002262993.1 50S ribosomal protein L13 -
F5989_RS05725 1150640..1150834 - 195 WP_002262994.1 helix-turn-helix transcriptional regulator -
F5989_RS05730 1150831..1151277 - 447 WP_002289426.1 hypothetical protein Antitoxin
F5989_RS05735 1151277..1151792 - 516 WP_002264864.1 hypothetical protein Toxin
F5989_RS05740 1151924..1152784 - 861 WP_002265709.1 DegV family protein -
F5989_RS05745 1152808..1153554 - 747 WP_002264862.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
F5989_RS05750 1153867..1154421 + 555 WP_002289424.1 PadR family transcriptional regulator -
F5989_RS05755 1154610..1155602 + 993 WP_002284724.1 BtrH N-terminal domain-containing protein -
F5989_RS05760 1155638..1156375 - 738 WP_002263001.1 MerR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1147196..1147324 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 172 a.a.        Molecular weight: 19540.17 Da        Isoelectric Point: 9.8779

>T140463 WP_002264864.1 NZ_CP044221:c1151792-1151277 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Download         Length: 516 bp

>T140463 NZ_CP059281:64283-64747 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 17024.34 Da        Isoelectric Point: 9.7659

>AT140463 WP_002289426.1 NZ_CP044221:c1151277-1150831 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIRLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK

Download         Length: 447 bp

>AT140463 NZ_CP059281:63948-64283 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References