Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | SmuAT/- |
Location | 1150831..1151792 | Replicon | chromosome |
Accession | NZ_CP044221 | ||
Organism | Streptococcus mutans strain NCH105 |
Toxin (Protein)
Gene name | smuT | Uniprot ID | - |
Locus tag | F5989_RS05735 | Protein ID | WP_002264864.1 |
Coordinates | 1151277..1151792 (-) | Length | 172 a.a. |
Antitoxin (Protein)
Gene name | smuA | Uniprot ID | - |
Locus tag | F5989_RS05730 | Protein ID | WP_002289426.1 |
Coordinates | 1150831..1151277 (-) | Length | 149 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F5989_RS05695 | 1146956..1147324 | - | 369 | Protein_1073 | transposase family protein | - |
F5989_RS05700 | 1147489..1148280 | + | 792 | WP_002289431.1 | nucleotidyltransferase domain-containing protein | - |
F5989_RS05705 | 1148485..1148817 | - | 333 | WP_002289429.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
F5989_RS05710 | 1148811..1149056 | - | 246 | WP_002262990.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
F5989_RS05715 | 1149378..1149770 | - | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
F5989_RS05720 | 1149795..1150241 | - | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
F5989_RS05725 | 1150640..1150834 | - | 195 | WP_002262994.1 | helix-turn-helix transcriptional regulator | - |
F5989_RS05730 | 1150831..1151277 | - | 447 | WP_002289426.1 | hypothetical protein | Antitoxin |
F5989_RS05735 | 1151277..1151792 | - | 516 | WP_002264864.1 | hypothetical protein | Toxin |
F5989_RS05740 | 1151924..1152784 | - | 861 | WP_002265709.1 | DegV family protein | - |
F5989_RS05745 | 1152808..1153554 | - | 747 | WP_002264862.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
F5989_RS05750 | 1153867..1154421 | + | 555 | WP_002289424.1 | PadR family transcriptional regulator | - |
F5989_RS05755 | 1154610..1155602 | + | 993 | WP_002284724.1 | BtrH N-terminal domain-containing protein | - |
F5989_RS05760 | 1155638..1156375 | - | 738 | WP_002263001.1 | MerR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | flank | IS/Tn | - | - | 1147196..1147324 | 128 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19540.17 Da Isoelectric Point: 9.8779
>T140463 WP_002264864.1 NZ_CP044221:c1151792-1151277 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T140463 NZ_CP059281:64283-64747 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 17024.34 Da Isoelectric Point: 9.7659
>AT140463 WP_002289426.1 NZ_CP044221:c1151277-1150831 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIRLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIRLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESIIKCSYLGLSGFWLICMGASVVYRHYLDKKEADK
Download Length: 447 bp
>AT140463 NZ_CP059281:63948-64283 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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