Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3388037..3388686 Replicon chromosome
Accession NZ_CP044218
Organism Mesorhizobium terrae strain NIBRBAC000500504

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C2DYX5
Locus tag FZF13_RS17620 Protein ID WP_024923650.1
Coordinates 3388037..3388426 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1C2DYW2
Locus tag FZF13_RS17625 Protein ID WP_024923649.1
Coordinates 3388423..3388686 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF13_RS17590 3383113..3383718 - 606 WP_024923655.1 TetR/AcrR family transcriptional regulator -
FZF13_RS17595 3383787..3384212 + 426 WP_024923654.1 VOC family protein -
FZF13_RS17600 3384326..3385237 + 912 WP_024927316.1 arginase family protein -
FZF13_RS17605 3385239..3386192 - 954 WP_024923652.1 trypsin-like peptidase domain-containing protein -
FZF13_RS17610 3386360..3387229 + 870 WP_024923651.1 S1C family serine protease -
FZF13_RS17615 3387383..3387982 + 600 WP_051504759.1 helix-turn-helix transcriptional regulator -
FZF13_RS17620 3388037..3388426 - 390 WP_024923650.1 type II toxin-antitoxin system VapC family toxin Toxin
FZF13_RS17625 3388423..3388686 - 264 WP_024923649.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FZF13_RS17630 3388853..3389719 + 867 WP_024923648.1 NAD(P)-dependent oxidoreductase -
FZF13_RS17635 3389747..3390271 - 525 WP_024923647.1 TIGR00645 family protein -
FZF13_RS17640 3390541..3392862 - 2322 WP_024923646.1 OmpA family protein -
FZF13_RS17645 3393027..3393476 + 450 WP_024923645.1 YcgN family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14072.21 Da        Isoelectric Point: 4.8892

>T140460 WP_024923650.1 NZ_CP044218:c3388426-3388037 [Mesorhizobium terrae]
VIVDTSVLIAILLAEEGFENYLRVLQQAPLKRIAAPTLLEATMVILGRKGEQGPELLDDLLRTAQIETTTFTPDHAAVAR
QAFLRYGKGRHAAGLNFGDCISYATAKLEAMPLLFKGDDFRQTDIEAAA

Download         Length: 390 bp

>T140460 NZ_CP059280:60450-60584 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9984.44 Da        Isoelectric Point: 5.2300

>AT140460 WP_024923649.1 NZ_CP044218:c3388686-3388423 [Mesorhizobium terrae]
MALSIKNAQVEKLARELARRRRVSVTEAIRQSLEREVARERLVPREAPNDMYNKLMAIVERSALIPTDTDLTEDEILGYD
EFGIPSK

Download         Length: 264 bp

>AT140460 NZ_CP059280:c60405-60345 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2DYX5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C2DYW2

References