Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-Phd
Location 2093248..2093915 Replicon chromosome
Accession NZ_CP044218
Organism Mesorhizobium terrae strain NIBRBAC000500504

Toxin (Protein)


Gene name vapC Uniprot ID A0A1C2DEW5
Locus tag FZF13_RS11380 Protein ID WP_024923037.1
Coordinates 2093248..2093649 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1C2DEW9
Locus tag FZF13_RS11385 Protein ID WP_024923036.1
Coordinates 2093661..2093915 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FZF13_RS11360 2088551..2089417 + 867 WP_024923041.1 LysR family transcriptional regulator -
FZF13_RS11365 2089428..2091383 - 1956 WP_024923040.1 acetate--CoA ligase -
FZF13_RS11370 2091675..2091947 + 273 WP_024923039.1 aspartate-semialdehyde dehydrogenase -
FZF13_RS11375 2092076..2093182 + 1107 WP_024923038.1 branched-chain amino acid ABC transporter substrate-binding protein -
FZF13_RS11380 2093248..2093649 - 402 WP_024923037.1 type II toxin-antitoxin system VapC family toxin Toxin
FZF13_RS11385 2093661..2093915 - 255 WP_024923036.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FZF13_RS11390 2093985..2094647 - 663 WP_024923035.1 YggS family pyridoxal phosphate-dependent enzyme -
FZF13_RS11395 2094801..2097440 + 2640 WP_024923034.1 leucine--tRNA ligase -
FZF13_RS11400 2097427..2098002 + 576 WP_024923033.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-60)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14711.91 Da        Isoelectric Point: 8.7791

>T140459 WP_024923037.1 NZ_CP044218:c2093649-2093248 [Mesorhizobium terrae]
MFLLDTNVVSAARKRQPAVTKWLADRERGDLSLSVVTLGEIARGIHMKQRHDPTTANHLAVWLQMLRHDYGNRILGIDER
IAIEWGRIAALRTRGVPDGLIAATAAVHGLTIVTRNVADFEDTGLAIVNPWAD

Download         Length: 402 bp

>T140459 NZ_CP059280:22356-22514 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9553.73 Da        Isoelectric Point: 4.8359

>AT140459 WP_024923036.1 NZ_CP044218:c2093915-2093661 [Mesorhizobium terrae]
MNWHLQDAKNNLSKLVQRAREEGPQTITLRGKPAAVVLSAEEYEALSAKKPSLAEFLLTGPVWDDDFVEEVNRRDKTPSR
DIDF

Download         Length: 255 bp

>AT140459 NZ_CP059280:22245-22310 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C2DEW5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C2DEW9

References