Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4786528..4787093 Replicon chromosome
Accession NZ_CP044211
Organism Rhodococcus ruber strain C1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag F1734_RS21865 Protein ID WP_124258608.1
Coordinates 4786528..4786884 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag F1734_RS21870 Protein ID WP_124258630.1
Coordinates 4786881..4787093 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F1734_RS21840 4782737..4783234 - 498 WP_124258612.1 hypothetical protein -
F1734_RS21845 4783598..4784656 - 1059 WP_124258611.1 beta-mannosidase -
F1734_RS21850 4784843..4785091 + 249 WP_124258610.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
F1734_RS21855 4785088..4785468 + 381 WP_043804893.1 type II toxin-antitoxin system VapC family toxin -
F1734_RS21860 4785626..4786465 + 840 WP_124258609.1 hypothetical protein -
F1734_RS21865 4786528..4786884 - 357 WP_124258608.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F1734_RS21870 4786881..4787093 - 213 WP_124258630.1 ribbon-helix-helix protein, CopG family Antitoxin
F1734_RS21875 4787305..4787886 + 582 WP_124258607.1 GNAT family N-acetyltransferase -
F1734_RS21880 4787894..4788925 - 1032 WP_124258606.1 hypothetical protein -
F1734_RS21885 4789148..4790431 + 1284 WP_140188857.1 competence/damage-inducible protein A -
F1734_RS21890 4790876..4791787 + 912 WP_140189163.1 formylglycine-generating enzyme family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - bsh 4771387..4787126 15739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-114)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12839.54 Da        Isoelectric Point: 7.3227

>T140456 WP_124258608.1 NZ_CP044211:c4786884-4786528 [Rhodococcus ruber]
MIRRAQIHWVDPDPAQGSEAAERRPAVVVSNDRANATAENLGRGVVTVVPLTTNTSHVFPFQVLVEPDESGLTRAAKAQA
EQVRSVSVRRLDTEPVGKLGARTLAALEEALRLHLDLR

Download         Length: 357 bp

>T140456 NZ_CP059279:c4828907-4828380 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7688.48 Da        Isoelectric Point: 4.4055

>AT140456 WP_124258630.1 NZ_CP044211:c4787093-4786881 [Rhodococcus ruber]
MTVKFTISLPDEDAHVLDEYIRDHGLRGRSAGVRAAVRLLAAAGLERDYATAFAEVDTEHAWDVTTADTE

Download         Length: 213 bp

>AT140456 NZ_CP059279:c4829180-4828914 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References