Detailed information of TA system TA140453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /GNAT-DUF1778
• Location: 2432771..2433537
• Replicon: chromosome
• Accession: NZ_CP044206
• Organism: Vibrio vulnificus strain Vv180806

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: F6X00_RS12145
• Protein ID: WP_182289778.1
• Coordinates: 2432771..2433268 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: F6X00_RS12150
• Protein ID: WP_130195056.1
• Coordinates: 2433265..2433537 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6X00_RS12080	2427781..2427870	+	90	WP_072829120.1	DUF3265 domain-containing protein	-
F6X00_RS12085	2428222..2428383	+	162	WP_103277107.1	DUF3265 domain-containing protein	-
F6X00_RS12090	2428343..2428798	+	456	WP_065090402.1	GNAT family N-acetyltransferase	-
F6X00_RS12095	2428947..2429411	+	465	WP_011080386.1	ASCH domain-containing protein	-
F6X00_RS12100	2429416..2429538	+	123	WP_081280336.1	DUF3265 domain-containing protein	-
F6X00_RS12105	2429559..2429954	+	396	WP_065090397.1	ACT domain-containing protein	-
F6X00_RS12110	2430450..2430578	+	129	Protein_2312	DUF3265 domain-containing protein	-
F6X00_RS12115	2430923..2431045	+	123	Protein_2313	DUF3265 domain-containing protein	-
F6X00_RS12120	2431088..2431480	+	393	WP_182289776.1	hypothetical protein	-
F6X00_RS12125	2431809..2432165	+	357	WP_182290960.1	hypothetical protein	-
F6X00_RS12130	2432180..2432272	+	93	WP_080640453.1	DUF3265 domain-containing protein	-
F6X00_RS12135	2432301..2432630	+	330	WP_011080397.1	hypothetical protein	-
F6X00_RS12140	2432627..2432737	+	111	WP_080538380.1	DUF3265 domain-containing protein	-
F6X00_RS12145	2432771..2433268	-	498	WP_182289778.1	GNAT family N-acetyltransferase	Toxin
F6X00_RS12150	2433265..2433537	-	273	WP_130195056.1	DUF1778 domain-containing protein	Antitoxin
F6X00_RS12155	2433617..2433739	+	123	WP_130195055.1	DUF3265 domain-containing protein	-
F6X00_RS12160	2433749..2434228	+	480	WP_025580509.1	hypothetical protein	-
F6X00_RS12165	2434225..2434347	+	123	WP_103198210.1	DUF3265 domain-containing protein	-
F6X00_RS12170	2434912..2435445	+	534	WP_182289780.1	hypothetical protein	-
F6X00_RS12175	2435397..2435552	+	156	WP_130195038.1	DUF3265 domain-containing protein	-
F6X00_RS12180	2435823..2435944	+	122	Protein_2326	DUF3265 domain-containing protein	-
F6X00_RS12185	2435961..2436323	+	363	WP_011150416.1	hypothetical protein	-
F6X00_RS12190	2436467..2436946	+	480	WP_001100124.1	GNAT family N-acetyltransferase	-
F6X00_RS12195	2437083..2437555	+	473	Protein_2329	GNAT family N-acetyltransferase	-
F6X00_RS12200	2437552..2437662	+	111	Protein_2330	DUF3265 domain-containing protein	-
F6X00_RS12205	2437672..2437917	+	246	WP_182289782.1	hypothetical protein	-
F6X00_RS12210	2438086..2438211	+	126	WP_130195066.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	2163050..2680424	517374
	-	inside	Integron	-	-	2402858..2445153	42295

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (86-152)

Antitoxin

• Vibrio phage ICP1, Orf50 (7-86)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18474.11 Da
• Isoelectric Point: 7.3556

>T140453 WP_182289778.1 NZ_CP044206:c2433268-2432771 [Vibrio vulnificus]
MMNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDSSHIIGFYTLTMTPIDLKSLPDKLQIKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFEDAENKLFITIADV
RASLG

Nucleotide

• Length: 498 bp

>T140453 NZ_CP059279:4301947-4302324 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAAAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9791.33 Da
• Isoelectric Point: 8.5961

>AT140453 WP_130195056.1 NZ_CP044206:c2433537-2433265 [Vibrio vulnificus]
MATTLPRITARVDVDTQDLLTKAAAIAGMSSINSFVLSAAIEKAKQVIEREQTLKLSQADAMLLMEALDRPATQNSKLKA
AAERYESKIQ

Nucleotide

• Length: 273 bp

>AT140453 NZ_CP059279:4301490-4301870 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGGGGCCGGT
TCAACAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG