Detailed information of TA system TA140452

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafN(antitoxin)
• Location: 2390783..2391348
• Replicon: chromosome
• Accession: NZ_CP044206
• Organism: Vibrio vulnificus strain Vv180806

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F6X00_RS11745
• Protein ID: WP_045390295.1
• Coordinates: 2391061..2391348 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3NI65
• Locus tag: F6X00_RS11740
• Protein ID: WP_011080399.1
• Coordinates: 2390783..2391064 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6X00_RS11685	2386193..2386594	+	402	WP_182289731.1	hypothetical protein	-
F6X00_RS11690	2386807..2387076	+	270	WP_182289733.1	hypothetical protein	-
F6X00_RS11695	2387093..2387215	+	123	Protein_2229	DUF3265 domain-containing protein	-
F6X00_RS11700	2387355..2387669	+	315	WP_182289735.1	superinfection immunity protein	-
F6X00_RS11705	2387838..2388071	+	234	WP_043921010.1	hypothetical protein	-
F6X00_RS11710	2388541..2388705	+	165	WP_182290931.1	DUF3265 domain-containing protein	-
F6X00_RS11715	2388737..2389441	+	705	WP_086610556.1	HNH endonuclease	-
F6X00_RS11720	2389438..2389566	+	129	WP_182290933.1	DUF3265 domain-containing protein	-
F6X00_RS11725	2389921..2390064	+	144	Protein_2235	DUF3265 domain-containing protein	-
F6X00_RS11730	2390051..2390584	+	534	WP_157402065.1	(d)CMP kinase	-
F6X00_RS11735	2390581..2390760	+	180	WP_182290935.1	DUF3265 domain-containing protein	-
F6X00_RS11740	2390783..2391064	+	282	WP_011080399.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F6X00_RS11745	2391061..2391348	+	288	WP_045390295.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F6X00_RS11750	2391494..2391964	+	471	WP_061058549.1	hypothetical protein	-
F6X00_RS11755	2392270..2392530	+	261	WP_043877387.1	DUF4282 domain-containing protein	-
F6X00_RS11760	2392517..2392708	+	192	WP_182290937.1	DUF3265 domain-containing protein	-
F6X00_RS11765	2392687..2393073	+	387	WP_000260420.1	tautomerase family protein	-
F6X00_RS11770	2393070..2393211	+	142	Protein_2244	DUF3265 domain-containing protein	-
F6X00_RS11775	2393227..2393511	+	285	WP_182289737.1	nucleotide pyrophosphohydrolase	-
F6X00_RS11780	2393489..2393629	+	141	WP_140265731.1	DUF3265 domain-containing protein	-
F6X00_RS11785	2393957..2394097	+	141	WP_182290939.1	DUF3265 domain-containing protein	-
F6X00_RS11790	2394199..2394564	+	366	WP_182289739.1	hypothetical protein	-
F6X00_RS11795	2394561..2394701	+	141	WP_182290941.1	DUF3265 domain-containing protein	-
F6X00_RS11800	2394840..2396048	+	1209	WP_103277394.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	2163050..2680424	517374
	-	inside	Integron	-	-	2268354..2394564	126210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11000.68 Da
• Isoelectric Point: 5.0872

>T140452 WP_045390295.1 NZ_CP044206:2391061-2391348 [Vibrio vulnificus]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTELLSNMPEMGRMVPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV

Nucleotide

• Length: 288 bp

>T140452 NZ_CP059279:c4149848-4149441 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10426.96 Da
• Isoelectric Point: 5.8719

>AT140452 WP_011080399.1 NZ_CP044206:2390783-2391064 [Vibrio vulnificus]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK

Nucleotide

• Length: 282 bp

>AT140452 NZ_CP059279:c4150095-4149829 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0MQY5