Detailed information of TA system TA140450

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 2375994..2376510
• Replicon: chromosome
• Accession: NZ_CP044206
• Organism: Vibrio vulnificus strain Vv180806

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F6X00_RS11580
• Protein ID: WP_005492798.1
• Coordinates: 2376241..2376510 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: F6X00_RS11575
• Protein ID: WP_005492799.1
• Coordinates: 2375994..2376248 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6X00_RS11520	2371483..2371824	+	342	WP_157402018.1	hypothetical protein	-
F6X00_RS11525	2371847..2372374	+	528	WP_182290914.1	DUF3265 domain-containing protein	-
F6X00_RS11530	2372519..2372968	+	450	WP_045623918.1	GNAT family N-acetyltransferase	-
F6X00_RS11535	2372947..2373093	+	147	WP_182290917.1	DUF3265 domain-containing protein	-
F6X00_RS11540	2373435..2373563	+	129	WP_085050392.1	DUF3265 domain-containing protein	-
F6X00_RS11545	2373905..2374027	+	123	WP_140244930.1	DUF3265 domain-containing protein	-
F6X00_RS11550	2374061..2374381	+	321	WP_108654789.1	DUF2834 domain-containing protein	-
F6X00_RS11555	2374318..2374572	+	255	Protein_2201	DUF3265 domain-containing protein	-
F6X00_RS11560	2374535..2375287	+	753	WP_182289729.1	SDR family oxidoreductase	-
F6X00_RS11565	2375469..2375699	-	231	WP_011150352.1	PAS factor family protein	-
F6X00_RS11570	2375738..2375902	+	165	WP_182290919.1	DUF3265 domain-containing protein	-
F6X00_RS11575	2375994..2376248	+	255	WP_005492799.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
F6X00_RS11580	2376241..2376510	+	270	WP_005492798.1	Txe/YoeB family addiction module toxin	Toxin
F6X00_RS11585	2376512..2376709	+	198	WP_182290921.1	DUF3265 domain-containing protein	-
F6X00_RS11590	2376747..2377079	+	333	WP_012600340.1	type II toxin-antitoxin system RelE/ParE family toxin	-
F6X00_RS11595	2377066..2377380	+	315	WP_017049537.1	DNA-binding transcriptional regulator	-
F6X00_RS11600	2377377..2377487	+	111	WP_072611830.1	DUF3265 domain-containing protein	-
F6X00_RS11605	2377514..2378134	+	621	WP_024699544.1	hypothetical protein	-
F6X00_RS11610	2378254..2378865	+	612	WP_025611401.1	hypothetical protein	-
F6X00_RS11615	2378899..2378988	+	90	WP_172572449.1	DUF3265 domain-containing protein	-
F6X00_RS11620	2379336..2379521	+	186	WP_182290923.1	DUF3265 domain-containing protein	-
F6X00_RS11625	2379537..2379842	+	306	WP_038964759.1	NIPSNAP family protein	-
F6X00_RS11630	2380324..2380434	+	111	WP_182290925.1	DUF3265 domain-containing protein	-
F6X00_RS11635	2380467..2380787	+	321	WP_070225643.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	flp1 / VP1611	2163050..2680424	517374
	-	inside	Integron	-	-	2268354..2394564	126210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10557.95 Da
• Isoelectric Point: 8.8578

>T140450 WP_005492798.1 NZ_CP044206:2376241-2376510 [Vibrio vulnificus]
MSSSQRLLSWTDDAWSDYLYWQTQDKKTLKRINKLITDVKRSPFEGIGKPEPLKENLAGFWSRRIDDTNRLVYAVDDQAL
TIISCRYHY

Nucleotide

• Length: 270 bp

>T140450 NZ_CP059279:c3132180-3131926 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9498.68 Da
• Isoelectric Point: 5.1007

>AT140450 WP_005492799.1 NZ_CP044206:2375994-2376248 [Vibrio vulnificus]
MRIVSFTEARNSLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPENAEHLKRSIAQYRAGKTTARE
LIDE

Nucleotide

• Length: 255 bp

>AT140450 NZ_CP059279:c3132428-3132177 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA