Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2339260..2339798 Replicon chromosome
Accession NZ_CP044206
Organism Vibrio vulnificus strain Vv180806

Toxin (Protein)


Gene name parE Uniprot ID A0A3Q0L5T8
Locus tag F6X00_RS11205 Protein ID WP_001247271.1
Coordinates 2339260..2339559 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0F2HR74
Locus tag F6X00_RS11210 Protein ID WP_011080384.1
Coordinates 2339556..2339798 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6X00_RS11160 2334748..2335155 + 408 WP_001900222.1 hypothetical protein -
F6X00_RS11165 2335133..2335288 + 156 WP_182289689.1 DUF3265 domain-containing protein -
F6X00_RS11170 2335624..2335752 + 129 WP_182290889.1 DUF3265 domain-containing protein -
F6X00_RS11175 2336094..2336255 + 162 WP_182290891.1 DUF3265 domain-containing protein -
F6X00_RS11180 2336332..2336619 + 288 WP_017817947.1 hypothetical protein -
F6X00_RS11185 2336802..2337620 + 819 WP_182289691.1 hypothetical protein -
F6X00_RS11190 2338256..2338681 + 426 WP_182289693.1 hypothetical protein -
F6X00_RS11195 2338678..2338806 + 129 WP_072606176.1 DUF3265 domain-containing protein -
F6X00_RS11200 2339141..2339326 + 186 WP_182290893.1 DUF3265 domain-containing protein -
F6X00_RS11205 2339260..2339559 - 300 WP_001247271.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F6X00_RS11210 2339556..2339798 - 243 WP_011080384.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
F6X00_RS11215 2339848..2339991 + 144 WP_182289695.1 DUF3265 domain-containing protein -
F6X00_RS11220 2340469..2340759 - 291 WP_025536831.1 type II toxin-antitoxin system RelE/ParE family toxin -
F6X00_RS11225 2340749..2340997 - 249 WP_005377003.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
F6X00_RS11230 2341193..2341762 + 570 WP_140075496.1 hypothetical protein -
F6X00_RS11235 2342380..2342832 + 453 WP_182289697.1 DUF4065 domain-containing protein -
F6X00_RS11240 2342813..2343388 + 576 WP_182289699.1 hypothetical protein -
F6X00_RS11245 2343401..2343511 + 111 WP_182290895.1 DUF3265 domain-containing protein -
F6X00_RS11250 2343538..2344152 + 615 WP_182289701.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - flp1 / VP1611 2163050..2680424 517374
- inside Integron - - 2268354..2394564 126210


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11703.39 Da        Isoelectric Point: 9.9572

>T140447 WP_001247271.1 NZ_CP044206:c2339559-2339260 [Vibrio vulnificus]
MRPFQLTNKAKSDLRDIALFTSRRWGREQRNIYLKQFDDSFWLLAENPDIGKACDEIRDGYRKFPQGSHVIFYRQIGSQN
IEIIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T140447 NZ_CP059279:c2623745-2622423 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8953.88 Da        Isoelectric Point: 4.2213

>AT140447 WP_011080384.1 NZ_CP044206:c2339798-2339556 [Vibrio vulnificus]
MAKNTSITLGDHFDGFIANQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGEESGVADYDLDSFINELDSEERK

Download         Length: 243 bp

>AT140447 NZ_CP059279:c2624011-2623745 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q0L5T8

Antitoxin

Source ID Structure
AlphaFold DB A0A0F2HR74

References