Detailed information of TA system TA140445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 906748..908423
• Replicon: chromosome
• Accession: NZ_CP044206
• Organism: Vibrio vulnificus strain Vv180806

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: F6X00_RS04210
• Protein ID: WP_182290519.1
• Coordinates: 907212..908423 (+)
• Length: 404 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: A0A0X8LPP8
• Locus tag: F6X00_RS04205
• Protein ID: WP_000649312.1
• Coordinates: 906748..907215 (+)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F6X00_RS04170	902150..902326	-	177	WP_182290505.1	hypothetical protein	-
F6X00_RS04175	902330..902773	-	444	WP_182290507.1	DUF2787 domain-containing protein	-
F6X00_RS04180	902831..903268	-	438	WP_182290509.1	DUF2787 domain-containing protein	-
F6X00_RS04185	903265..903738	-	474	WP_182290511.1	DNA repair protein RadC	-
F6X00_RS04190	903955..904092	+	138	WP_182290513.1	hypothetical protein	-
F6X00_RS04195	904157..905794	+	1638	WP_182290515.1	RNA-directed DNA polymerase	-
F6X00_RS04200	905821..906528	+	708	WP_182290517.1	hypothetical protein	-
F6X00_RS04205	906748..907215	+	468	WP_000649312.1	DUF4065 domain-containing protein	Antitoxin
F6X00_RS04210	907212..908423	+	1212	WP_182290519.1	RelA/SpoT domain-containing protein	Toxin
F6X00_RS04215	908596..909705	-	1110	WP_182290521.1	tRNA (uridine(54)-C5)-methyltransferase TrmA	-
F6X00_RS04220	910049..911455	+	1407	WP_011149137.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	887008..946612	59604

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (111-228)

Antitoxin

• Antitoxin SocA-like, Panacea domain (32-123)

Sequences

Toxin

Protein

• Length: 404 a.a.
• Molecular weight: 45738.52 Da
• Isoelectric Point: 5.1689

>T140445 WP_182290519.1 NZ_CP044206:907212-908423 [Vibrio vulnificus]
VSDKEKRVVSFQIDDTPTAEQASKNFQDDYELCFQDFLERTVDESAAEDFSYSNNGVKKAGRRLRKKEGDLKSATATIQQ
FRAAHEKPLNTIAYLVGRCCRELGIDVKPVTRLKRLETIVDKLQRKSLDGETANATCVTNMNDIGGCRAIFPDLESLEKA
KESLQVTVEKVGRIKIKDIDDYITNPKPNDCGYRSLHVIYRYDHASGKSFNIEAQLRTRLQHLWATTVEIVDILEGTKIK
THSHSPDEDKEKLQVQWEELLSIMSQYIADAEGAIELSNDNRTQFSNRLIELNREINALSRLRSFKILSEKVEGCRDGSI
EHVLLVIDETSLEMIFSEEFENYTQAISVYNAAEKMTRSHARLNTLLISTKNMGQLSEAYPNYLGDCASFITLLEDAMQS
GQN

Nucleotide

• Length: 1212 bp

>T140445 NZ_CP059279:c2181036-2180758 [Escherichia coli]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCTGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTAGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17581.02 Da
• Isoelectric Point: 7.5659

>AT140445 WP_000649312.1 NZ_CP044206:906748-907215 [Vibrio vulnificus]
MKAYHTYSAVDVAWSLLKHAKEQGKCFSNLQLQKLTYVCHGLSLAHFQRPLVVDDVFAWKFGPVVPSVYFRFKSYGSNVI
TEQCDVVLDHESESIVKDVVSQLGHLTGPQLVDLTHREGSPWHQVWDGTHQKVIPDHLIQAHYTQIKQSGRTASL

Nucleotide

• Length: 468 bp

>AT140445 NZ_CP059279:c2181229-2181038 [Escherichia coli]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAATTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAGATGCGTAAGGAACGGAGCAAGCAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0X8LPP8