Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3981203..3981840 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag F6R98_RS18125 Protein ID WP_153250266.1
Coordinates 3981433..3981840 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag F6R98_RS18120 Protein ID WP_153250265.1
Coordinates 3981203..3981433 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS18080 3976662..3977105 - 444 WP_153251133.1 GNAT family N-acetyltransferase -
F6R98_RS18085 3977092..3977553 - 462 WP_153250259.1 carboxymuconolactone decarboxylase family protein -
F6R98_RS18090 3977670..3979217 + 1548 WP_153250260.1 PLP-dependent aminotransferase family protein -
F6R98_RS18100 3979521..3979814 - 294 WP_153250262.1 BrnA antitoxin family protein -
F6R98_RS18105 3979786..3980072 - 287 Protein_3591 BrnT family toxin -
F6R98_RS18110 3980320..3980508 + 189 WP_153250263.1 hypothetical protein -
F6R98_RS18115 3980565..3981035 - 471 WP_153250264.1 GNAT family N-acetyltransferase -
F6R98_RS18120 3981203..3981433 + 231 WP_153250265.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F6R98_RS18125 3981433..3981840 + 408 WP_153250266.1 type II toxin-antitoxin system VapC family toxin Toxin
F6R98_RS18130 3982564..3984501 - 1938 WP_153250267.1 RNA-directed DNA polymerase -
F6R98_RS18135 3984494..3985675 - 1182 WP_153250268.1 hypothetical protein -
F6R98_RS18140 3985863..3986235 - 373 Protein_3598 type II toxin-antitoxin system death-on-curing family toxin -
F6R98_RS18145 3986232..3986459 - 228 WP_153250269.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-127)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15315.53 Da        Isoelectric Point: 6.6421

>T140444 WP_153250266.1 NZ_CP044205:3981433-3981840 [Candidatus Methylospira mobilis]
MAVRYLLDTNICIYIAKHNPPQVRERFALHAADELAMSVITLGELRFGAEKSQYRERALGVISQLAAMMQIAELTETVAE
HYGQIRTALQRNGQIIGNNDLWLAAHARAEGWILVTHNEREFTRVDGLKVENWSV

Download         Length: 408 bp

>T140444 NZ_CP059279:1540797-1541099 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8700.82 Da        Isoelectric Point: 7.0121

>AT140444 WP_153250265.1 NZ_CP044205:3981203-3981433 [Candidatus Methylospira mobilis]
MAYARVFQSGNSQAVRLPKEFRFKTGKVEIFRRGNEIVLREQADNALAIFEALSSLPDDFLEQGRGDMPPQHRDSF

Download         Length: 231 bp

>AT140444 NZ_CP059279:1541135-1541476 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References