Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3717176..3717777 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F6R98_RS16930 Protein ID WP_153250064.1
Coordinates 3717601..3717777 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F6R98_RS16925 Protein ID WP_153251117.1
Coordinates 3717176..3717589 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS16905 3712471..3713919 - 1449 WP_153250061.1 efflux transporter outer membrane subunit -
F6R98_RS16910 3713922..3715529 - 1608 WP_153250062.1 DHA2 family efflux MFS transporter permease subunit -
F6R98_RS16915 3715807..3716634 + 828 WP_153250063.1 orotidine-5'-phosphate decarboxylase -
F6R98_RS16920 3716655..3717182 + 528 Protein_3354 recombinase family protein -
F6R98_RS16925 3717176..3717589 - 414 WP_153251117.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F6R98_RS16930 3717601..3717777 - 177 WP_153250064.1 mRNA interferase Toxin
F6R98_RS16935 3718038..3718664 + 627 WP_153250065.1 HNH endonuclease -
F6R98_RS16940 3718670..3719266 - 597 WP_153250066.1 recombinase family protein -
F6R98_RS16945 3719847..3720887 - 1041 Protein_3359 IS110 family transposase -
F6R98_RS16950 3721311..3722617 + 1307 Protein_3360 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-80)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.09 Da        Isoelectric Point: 11.1422

>T140443 WP_153250064.1 NZ_CP044205:c3717777-3717601 [Candidatus Methylospira mobilis]
MKLSEFARWLKSQGVSFKEGKKHTKLFFNGMQSTLPRHVVEIKEPLRKAIIKQLGLKE

Download         Length: 177 bp

>T140443 NZ_CP059279:c1511843-1511625 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCTGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15302.68 Da        Isoelectric Point: 4.9627

>AT140443 WP_153251117.1 NZ_CP044205:c3717589-3717176 [Candidatus Methylospira mobilis]
MRYPVNIEPAESGFFVSFPDIPEALTQGETFAEALAMGKDALETALEFYFEDERAVPLPSKPEPGQSVVDLSPSLWAKVL
LLNEMVAQHVRPVDLARKLSIRPQEVTRLMRLRHPTKIDTISSALNAMGKSLELFVH

Download         Length: 414 bp

>AT140443 NZ_CP059279:c1512243-1511869 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References