Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 3671107..3671481 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F6R98_RS16700 Protein ID WP_153251114.1
Coordinates 3671299..3671481 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F6R98_RS16695 Protein ID WP_194269989.1
Coordinates 3671107..3671286 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS16675 3666199..3668016 + 1818 WP_153250024.1 hypothetical protein -
F6R98_RS16680 3668143..3668922 + 780 WP_153250025.1 DUF2272 domain-containing protein -
F6R98_RS16685 3669102..3669416 + 315 WP_153250026.1 FlxA-like family protein -
F6R98_RS16690 3669480..3671048 + 1569 WP_153250027.1 tetratricopeptide repeat-containing glycosyltransferase family protein -
F6R98_RS16695 3671107..3671286 - 180 WP_194269989.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F6R98_RS16700 3671299..3671481 - 183 WP_153251114.1 type II toxin-antitoxin system HicA family toxin Toxin
F6R98_RS16705 3672018..3672230 - 213 WP_153251115.1 hypothetical protein -
F6R98_RS16710 3672631..3673395 - 765 WP_153250028.1 IS5 family transposase -
F6R98_RS16715 3673715..3674182 - 468 WP_153250029.1 Lrp/AsnC family transcriptional regulator -
F6R98_RS16720 3674348..3676039 + 1692 WP_153250030.1 2-isopropylmalate synthase -
F6R98_RS16725 3676195..3676443 + 249 WP_153250031.1 type II toxin-antitoxin system prevent-host-death family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(7-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-58)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6587.58 Da        Isoelectric Point: 10.6823

>T140442 WP_153251114.1 NZ_CP044205:c3671481-3671299 [Candidatus Methylospira mobilis]
IKVNETLAAMLNMDGWYLATTRGSHRQFKHPIKSGRVTVPGKPNDDLAPGTLNSILKQAQ

Download         Length: 183 bp

>T140442 NZ_CP059279:1362255-1363175 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCAGGCAGGTTAAACTGTTGATGGCCGCTCTGCCGCATGTGGCGAAGGAATCCTGTTT
CGCGTTGAAAGGCGGCACAGCAATCAATTTATTTGTGCAGGATTTCCCCCGTCTATCGGTGGATATCGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACCGATCTGGCGGCGATCAACGACGCTTTGAAGAGAATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATATGTGCTGCGCTTGATCGTCAGCAT
CCGCGCGATCTGTTTGATGTGTTGAATATGCTGGGGAGACCGGGCCTGACGCGCGAAATTTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGTCCCATTGCCGAGTTGCTGGCTTCAAACTGGGATACAGATCGGATTGCCACGTTATACGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTTCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATTTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGCAATCTGGCGATGCTTAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGAGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6735.65 Da        Isoelectric Point: 4.3344

>AT140442 WP_194269989.1 NZ_CP044205:c3671286-3671107 [Candidatus Methylospira mobilis]
MRYAIVVEKTENNYSAYVPDLPGCVATGFTVEEIEREIREAIQFHIEGLIEDGLPVPRR

Download         Length: 180 bp

>AT140442 NZ_CP059279:1361486-1362268 [Escherichia coli]
TTGCCAAACTATCTAAACTGGTTGATGCAAAACACGCTACCCGGTCAGGTGCTGCTCCAGTCATGGCTTACCCGCAATGG
CGTAGATCGTAAGCTTTCTTATCTCTATGTTCAGAATGGCTGGCTCAGGCGCATCGCTCACGGTGTGTACTGCCGGACGG
GCCGTGAGCCGGATTGGGTAGACGCGGTTTACTGCCTTCAAACACAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGCCATGCGCACTATACCGAACCGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTGCTGCCTTCGAACAATCAGCAACATTTATCACGCTGTATACATCGGGCCTTACCGTTGATGTCT
CGTCATTTACTACGGAACTGAAAATTGGCGACCGGCAGTTAGCAGGCAGTGCACCGGAACTGGCCGCGTATGAGATCGCC
TGCGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGGGGAATCTTCTCAGCCCACGCAAATT
GCAGGCACTGCTTCGCGCCAGTCATTCGATTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTATCTTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCTGGTGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCCCGCACATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References