Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3586317..3586939 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag F6R98_RS16330 Protein ID WP_153249962.1
Coordinates 3586646..3586939 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F6R98_RS16325 Protein ID WP_153249961.1
Coordinates 3586317..3586631 (-) Length 105 a.a.

Genomic Context

F6R98_RS16310F6R98_RS21695F6R98_RS16315F6R98_RS16320F6R98_RS21700F6R98_RS16335F6R98_RS16325F6R98_RS16330F6R98_RS16340F6R98_RS16345F6R98_RS16350F6R98_RS16355
Location: 3581913..3582419 (507 bp)
Type: Others
Protein ID: WP_153249959.1
Location: 3583119..3583307 (189 bp)
Type: Others
Protein ID: WP_194269985.1
Location: 3583375..3584897 (1523 bp)
Type: Others
Protein ID: Protein_3232
Location: 3584887..3585693 (807 bp)
Type: Others
Protein ID: WP_153249960.1
Location: 3587171..3587377 (207 bp)
Type: Others
Protein ID: WP_194270264.1
Location: 3587283..3587678 (396 bp)
Type: Others
Protein ID: WP_153249963.1
Location: 3586317..3586631 (315 bp)
Type: Antitoxin
Protein ID: WP_153249961.1
Location: 3586646..3586939 (294 bp)
Type: Toxin
Protein ID: WP_153249962.1
Location: 3587818..3588099 (282 bp)
Type: Others
Protein ID: WP_153249964.1
Location: 3588109..3588390 (282 bp)
Type: Others
Protein ID: WP_153249965.1
Location: 3588806..3589300 (495 bp)
Type: Others
Protein ID: WP_153249966.1
Location: 3589461..3590789 (1329 bp)
Type: Others
Protein ID: WP_153251109.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
F6R98_RS163103581913..3582419+507WP_153249959.1protein disulfide oxidoreductase-
F6R98_RS216953583119..3583307+189WP_194269985.1hypothetical protein-
F6R98_RS163153583375..3584897+1523Protein_3232IS21 family transposase-
F6R98_RS163203584887..3585693+807WP_153249960.1IS21-like element helper ATPase IstB-
F6R98_RS163253586317..3586631-315WP_153249961.1putative addiction module antidote proteinAntitoxin
F6R98_RS163303586646..3586939-294WP_153249962.1type II toxin-antitoxin system RelE/ParE family toxinToxin
F6R98_RS217003587171..3587377+207WP_194270264.1hypothetical protein-
F6R98_RS163353587283..3587678+396WP_153249963.1tyrosine-type recombinase/integrase-
F6R98_RS163403587818..3588099-282WP_153249964.1HigA family addiction module antidote protein-
F6R98_RS163453588109..3588390-282WP_153249965.1type II toxin-antitoxin system RelE/ParE family toxin-
F6R98_RS163503588806..3589300-495WP_153249966.1cytochrome-
F6R98_RS163553589461..3590789-1329WP_153251109.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-85)

Antitoxin

Cro/C1-type helix-turn-helix domain

(50-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10823.70 Da        Isoelectric Point: 10.6498

>T140441 WP_153249962.1 NZ_CP044205:c3586939-3586646 [Candidatus Methylospira mobilis]
MYIIKPLPNFTEWLDGLADEKTRGIISARIKRLERGLMGDVEPVGEGVSELRIHVGSGLRVYFTKRGARLIILLVGGSKS
TQKNDFKRAKQLATLLD

Download         Length: 294 bp

>T140441 NZ_CP059279:1095754-1096068 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11270.93 Da        Isoelectric Point: 5.1237

>AT140441 WP_153249961.1 NZ_CP044205:c3586631-3586317 [Candidatus Methylospira mobilis]
MTKRIKIDDLPEFDAAPYLSSEEAVAAYLTDILEANDAGLLAAALGDIARARGMTEISKLAGITREALYKALRPDSEPRI
DTINRVCSALGVRLVVQPTHLHPN

Download         Length: 315 bp

>AT140441 NZ_CP059279:1095518-1095751 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References