Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1343678..1344264 Replicon chromosome
Accession NZ_CP044205
Organism Candidatus Methylospira mobilis strain Shm1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag F6R98_RS05865 Protein ID WP_153248192.1
Coordinates 1343678..1343932 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag F6R98_RS05870 Protein ID WP_194270164.1
Coordinates 1343929..1344264 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F6R98_RS05840 1339417..1339845 + 429 WP_153248189.1 50S ribosomal protein L13 -
F6R98_RS05845 1339863..1340255 + 393 WP_153248190.1 30S ribosomal protein S9 -
F6R98_RS05855 1340993..1341799 - 807 WP_153248191.1 IS21-like element helper ATPase IstB -
F6R98_RS05860 1341789..1343312 - 1524 WP_153250922.1 IS21 family transposase -
F6R98_RS05865 1343678..1343932 + 255 WP_153248192.1 type II toxin-antitoxin system HicA family toxin Toxin
F6R98_RS05870 1343929..1344264 + 336 WP_194270164.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F6R98_RS05875 1344868..1345104 - 237 WP_153248193.1 hypothetical protein -
F6R98_RS05880 1345083..1345922 - 840 WP_194270165.1 hypothetical protein -
F6R98_RS05885 1346096..1346317 - 222 WP_153248195.1 DNA-binding protein -
F6R98_RS05890 1346430..1347842 + 1413 WP_153248196.1 hypothetical protein -
F6R98_RS05895 1347785..1348858 - 1074 WP_153248197.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-79)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9710.11 Da        Isoelectric Point: 9.9205

>T140437 WP_153248192.1 NZ_CP044205:1343678-1343932 [Candidatus Methylospira mobilis]
MKRKHQKTLELIYARPVGGNIQWRDIEALFVELGAEISEREGSRIEVFLFNEVRVFHRPHPRPDTDKGAVSSVREWLKAN
GVTP

Download         Length: 255 bp

>T140437 NZ_CP059279:706944-707117 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12445.14 Da        Isoelectric Point: 4.9267

>AT140437 WP_194270164.1 NZ_CP044205:1343929-1344264 [Candidatus Methylospira mobilis]
MMNRMIIDGYSAVIQYDPEIEMFRGEFTGLNGGADFYAKDIDNLKREGEISLRVFLDACRERGIAPKKTFSGKFNVRIPE
DLHADIVNAACAEGKSLNQWVAEALRREASA

Download         Length: 336 bp

>AT140437 NZ_CP059279:706620-706916 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCCGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References