Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 34913..35556 | Replicon | plasmid pAR-0405 |
| Accession | NZ_CP044204 | ||
| Organism | Salmonella enterica subsp. enterica serovar Senftenberg strain AR-0405 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | D8L2J9 |
| Locus tag | F4V17_RS23735 | Protein ID | WP_001044770.1 |
| Coordinates | 34913..35329 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | D5KTK7 |
| Locus tag | F4V17_RS23740 | Protein ID | WP_001261282.1 |
| Coordinates | 35326..35556 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F4V17_RS23700 | 30455..30691 | - | 237 | WP_000993386.1 | broad-spectrum mercury transporter MerE | - |
| F4V17_RS23705 | 30688..31050 | - | 363 | WP_001277456.1 | mercury resistance co-regulator MerD | - |
| F4V17_RS23710 | 31068..32762 | - | 1695 | WP_000105636.1 | mercury(II) reductase | - |
| F4V17_RS23715 | 32814..33236 | - | 423 | WP_001340589.1 | organomercurial transporter MerC | - |
| F4V17_RS23720 | 33272..33397 | - | 126 | WP_072093211.1 | mercury transporter | - |
| F4V17_RS23725 | 33398..34095 | - | 698 | Protein_34 | IS1 family transposase | - |
| F4V17_RS23730 | 34129..34839 | - | 711 | WP_004152334.1 | ATP-binding protein | - |
| F4V17_RS23735 | 34913..35329 | - | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| F4V17_RS23740 | 35326..35556 | - | 231 | WP_001261282.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| F4V17_RS23745 | 35513..35974 | + | 462 | WP_072202616.1 | hypothetical protein | - |
| F4V17_RS23750 | 36118..36468 | + | 351 | WP_000493378.1 | hypothetical protein | - |
| F4V17_RS23755 | 36519..37262 | + | 744 | WP_000129823.1 | hypothetical protein | - |
| F4V17_RS23760 | 37259..38035 | + | 777 | WP_000015958.1 | site-specific integrase | - |
| F4V17_RS23765 | 38093..38350 | - | 258 | WP_000764642.1 | hypothetical protein | - |
| F4V17_RS24015 | 38479..38583 | - | 105 | WP_032409716.1 | hypothetical protein | - |
| F4V17_RS23770 | 39113..39979 | + | 867 | WP_004118283.1 | replication initiation protein | - |
| F4V17_RS23775 | 40156..40425 | - | 270 | WP_000339857.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..60896 | 60896 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 20475.56 Da Isoelectric Point: 5.5500
>T140435 WP_001044770.1 NZ_CP044204:c35329-34913 [Salmonella enterica subsp. enterica serovar Senftenberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 417 bp
>T140435 NZ_CP059254:c2842551-2842189 [Streptomyces albidoflavus]
ATGGACGGGGAATGGCAGATCTTCCTGGTTGACGAGGTGCGTGTTTGGCTCGCGTCCCTCGACGGGGCCGCGCACGCACG
AGTGGTACAGGCGCTGGACGTGCTGGCCGAGGAAGGGCCTGCTCTCGGAAGACCGCTTGTGGACACCTTGCGTGGTTCAG
CGGTGGCCAATTTGAAAGAGCTCCGGCCCGGCACGGTCAGAATCCTGTTCGCCTTCGATCCGTGGCGTTCCAGCATCTTG
CTGGTGGCAGGTGACAAGTCCGGGCAGCGGACTGAGTGGTACCAGGAGGCGATCCCCCTGGCCGAGCAGCGCTACGCGCT
TTACTTGAAGGAACGTGAGCGGGAAGAGGGAGGACGACCATGA
ATGGACGGGGAATGGCAGATCTTCCTGGTTGACGAGGTGCGTGTTTGGCTCGCGTCCCTCGACGGGGCCGCGCACGCACG
AGTGGTACAGGCGCTGGACGTGCTGGCCGAGGAAGGGCCTGCTCTCGGAAGACCGCTTGTGGACACCTTGCGTGGTTCAG
CGGTGGCCAATTTGAAAGAGCTCCGGCCCGGCACGGTCAGAATCCTGTTCGCCTTCGATCCGTGGCGTTCCAGCATCTTG
CTGGTGGCAGGTGACAAGTCCGGGCAGCGGACTGAGTGGTACCAGGAGGCGATCCCCCTGGCCGAGCAGCGCTACGCGCT
TTACTTGAAGGAACGTGAGCGGGAAGAGGGAGGACGACCATGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 11350.61 Da Isoelectric Point: 5.5500
>AT140435 WP_001261282.1 NZ_CP044204:c35556-35326 [Salmonella enterica subsp. enterica serovar Senftenberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
Download Length: 231 bp
>AT140435 NZ_CP059254:c2842192-2841875 [Streptomyces albidoflavus]
ATGACGAGTTACACCCGTTGGCAGGACATTCGTCCCGAGCATGTCGCCCGCGCAGGGGGTGAGGAAGCCGTACGCGCGGG
TAAGGAGGAGCTGCTCGCGCAGGTCACCGGGAGGAAGCTCGCGGAGCTGCGTCGCGCCCGAGGGCTGACCCAGCAGGAGG
TGGCGGACCGGATGGGGGTCAGCAAGGGGCGGATCTCCCAGATCGAGCGGGGGCACCTTTCGGGACAGGAAGTGCTGGCC
CGATTCGCGACCGCTCTCGGAGGCCGTCTCCATCAGGCGATCTACTTCGACGACGGCGACATCGCCACCATCGCCTGA
ATGACGAGTTACACCCGTTGGCAGGACATTCGTCCCGAGCATGTCGCCCGCGCAGGGGGTGAGGAAGCCGTACGCGCGGG
TAAGGAGGAGCTGCTCGCGCAGGTCACCGGGAGGAAGCTCGCGGAGCTGCGTCGCGCCCGAGGGCTGACCCAGCAGGAGG
TGGCGGACCGGATGGGGGTCAGCAAGGGGCGGATCTCCCAGATCGAGCGGGGGCACCTTTCGGGACAGGAAGTGCTGGCC
CGATTCGCGACCGCTCTCGGAGGCCGTCTCCATCAGGCGATCTACTTCGACGACGGCGACATCGCCACCATCGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GYM2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GZG3 |