Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 81952..82595 Replicon plasmid pAR-0401-2
Accession NZ_CP044190
Organism Salmonella enterica subsp. enterica serovar Albert strain AR-0401

Toxin (Protein)


Gene name vagD Uniprot ID V0UN72
Locus tag F4V13_RS25575 Protein ID WP_001034044.1
Coordinates 82179..82595 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B1P7N7
Locus tag F4V13_RS25570 Protein ID WP_001261286.1
Coordinates 81952..82182 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V13_RS25540 78515..79270 - 756 WP_000852146.1 replication initiation protein RepE -
F4V13_RS25545 79992..80798 - 807 WP_000016970.1 site-specific integrase -
F4V13_RS25550 80799..81104 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
F4V13_RS25555 81106..81324 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA -
F4V13_RS25570 81952..82182 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
F4V13_RS25575 82179..82595 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin Toxin
F4V13_RS25580 82670..84234 + 1565 Protein_99 AAA family ATPase -
F4V13_RS25585 84219..85241 + 1023 WP_000361402.1 helicase UvrD -
F4V13_RS25590 85495..86181 - 687 Protein_101 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120390 120390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 17834.22 Da        Isoelectric Point: 12.9398

>T140434 WP_001034044.1 NZ_CP044190:82179-82595 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 417 bp

>T140434 NZ_CP059180:c2410399-2410133 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9887.42 Da        Isoelectric Point: 12.6808

>AT140434 WP_001261286.1 NZ_CP044190:81952-82182 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 231 bp

>AT140434 NZ_CP059180:c2410656-2410399 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CHW1

Antitoxin

Source ID Structure
AlphaFold DB A0A829CKZ6

References