Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 80799..81324 Replicon plasmid pAR-0401-2
Accession NZ_CP044190
Organism Salmonella enterica subsp. enterica serovar Albert strain AR-0401

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag F4V13_RS25550 Protein ID WP_001159871.1
Coordinates 80799..81104 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag F4V13_RS25555 Protein ID WP_000813630.1
Coordinates 81106..81324 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V13_RS25535 76761..77927 - 1167 WP_015059580.1 plasmid-partitioning protein SopA -
F4V13_RS25540 78515..79270 - 756 WP_000852146.1 replication initiation protein RepE -
F4V13_RS25545 79992..80798 - 807 WP_000016970.1 site-specific integrase -
F4V13_RS25550 80799..81104 - 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
F4V13_RS25555 81106..81324 - 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
F4V13_RS25570 81952..82182 + 231 WP_001261286.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
F4V13_RS25575 82179..82595 + 417 WP_001034044.1 type II toxin-antitoxin system VapC family toxin -
F4V13_RS25580 82670..84234 + 1565 Protein_99 AAA family ATPase -
F4V13_RS25585 84219..85241 + 1023 WP_000361402.1 helicase UvrD -
F4V13_RS25590 85495..86181 - 687 Protein_101 IS1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..120390 120390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T140433 WP_001159871.1 NZ_CP044190:c81104-80799 [Salmonella enterica subsp. enterica serovar Albert]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T140433 NZ_CP059180:c2353546-2353280 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT140433 WP_000813630.1 NZ_CP044190:c81324-81106 [Salmonella enterica subsp. enterica serovar Albert]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT140433 NZ_CP059180:c2353797-2353546 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References