Detailed information of TA system TA140432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 30533..31158
• Replicon: plasmid pAR-0401-2
• Accession: NZ_CP044190
• Organism: Salmonella enterica subsp. enterica serovar Albert strain AR-0401

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F4V13_RS25185
• Protein ID: WP_000911313.1
• Coordinates: 30760..31158 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: V0VCB2
• Locus tag: F4V13_RS25180
• Protein ID: WP_000450520.1
• Coordinates: 30533..30760 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4V13_RS25180	30533..30760	+	228	WP_000450520.1	toxin-antitoxin system antitoxin VapB	Antitoxin
F4V13_RS25185	30760..31158	+	399	WP_000911313.1	tRNA(fMet)-specific endonuclease VapC	Toxin
F4V13_RS25190	31167..33320	-	2154	WP_000009324.1	type IV conjugative transfer system coupling protein TraD	-
F4V13_RS25200	33573..34304	-	732	WP_023565183.1	complement resistance protein TraT	-
F4V13_RS25205	34336..34833	-	498	WP_000605859.1	entry exclusion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120390	120390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (14-92)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 17065.17 Da
• Isoelectric Point: 12.9205

>T140432 WP_000911313.1 NZ_CP044190:30760-31158 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 399 bp

>T140432 NZ_CP059180:c2031117-2030908 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 9759.25 Da
• Isoelectric Point: 12.6750

>AT140432 WP_000450520.1 NZ_CP044190:30533-30760 [Salmonella enterica subsp. enterica serovar Albert]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 228 bp

>AT140432 NZ_CP059180:c2031422-2031129 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Structures

Antitoxin

• AlphaFold DB: V0VCB2