Detailed information of TA system TA140431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 17277..17824
• Replicon: plasmid pAR-0401-2
• Accession: NZ_CP044190
• Organism: Salmonella enterica subsp. enterica serovar Albert strain AR-0401

Toxin (Protein)

• Gene name: parE
• Uniprot ID: E9LLH3
• Locus tag: F4V13_RS25095
• Protein ID: WP_000969996.1
• Coordinates: 17277..17558 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: K4JYR0
• Locus tag: F4V13_RS25100
• Protein ID: WP_000079928.1
• Coordinates: 17555..17824 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4V13_RS25055	12547..13362	-	816	WP_001043260.1	sulfonamide-resistant dihydropteroate synthase Sul2	-
F4V13_RS25065	13577..13849	+	273	WP_000019163.1	hypothetical protein	-
F4V13_RS25070	13830..15038	+	1209	WP_000198533.1	IS91 family transposase	-
F4V13_RS25075	15207..15632	-	426	Protein_15	DUF4238 domain-containing protein	-
F4V13_RS25080	15984..16238	+	255	WP_000343103.1	hypothetical protein	-
F4V13_RS25085	16238..16828	+	591	WP_000194550.1	hypothetical protein	-
F4V13_RS25090	16846..17192	-	347	Protein_18	hypothetical protein	-
F4V13_RS25095	17277..17558	-	282	WP_000969996.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F4V13_RS25100	17555..17824	-	270	WP_000079928.1	hypothetical protein	Antitoxin
F4V13_RS25115	18738..19514	-	777	WP_015059632.1	IncF replication protein RepA1	-
F4V13_RS25120	19507..19581	-	75	WP_001365705.1	RepA leader peptide Tap	-
F4V13_RS25130	19828..20076	-	249	WP_000083835.1	replication regulatory protein RepA	-
F4V13_RS25135	20360..20566	-	207	WP_001553767.1	type I toxin-antitoxin system Hok family toxin	-
F4V13_RS25145	20789..21171	-	383	Protein_25	hypothetical protein	-
F4V13_RS25150	21274..21735	-	462	WP_000760078.1	thermonuclease family protein	-
F4V13_RS25155	22478..22681	-	204	WP_001327131.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..120390	120390

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 13852.62 Da
• Isoelectric Point: 5.5500

>T140431 WP_000969996.1 NZ_CP044190:c17558-17277 [Salmonella enterica subsp. enterica serovar Albert]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Nucleotide

• Length: 282 bp

>T140431 NZ_CP059180:c2011513-2011151 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT140431 WP_000079928.1 NZ_CP044190:c17824-17555 [Salmonella enterica subsp. enterica serovar Albert]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT140431 NZ_CP059180:c2011680-2011510 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Toxin

• AlphaFold DB: E9LLH3

Antitoxin

• AlphaFold DB: A0A5W2J4D0