Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 83713..84260 Replicon plasmid pAR-0404-2
Accession NZ_CP044183
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain AR-0404

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag F4V16_RS24035 Protein ID WP_000970007.1
Coordinates 83979..84260 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag F4V16_RS24030 Protein ID WP_000079941.1
Coordinates 83713..83982 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V16_RS23985 79357..79890 - 534 WP_001303319.1 transcription termination factor NusG -
F4V16_RS23995 80332..80619 - 288 WP_000074849.1 conjugal transfer protein TraA -
F4V16_RS24000 80537..80800 - 264 WP_001324596.1 ash family protein -
F4V16_RS24015 81773..82804 + 1032 WP_000907873.1 replication initiation protein -
F4V16_RS24030 83713..83982 + 270 WP_000079941.1 hypothetical protein Antitoxin
F4V16_RS24035 83979..84260 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V16_RS24040 84300..85148 + 849 WP_001057991.1 3'-5' exonuclease -
F4V16_RS24045 85265..85738 + 474 WP_001334658.1 hypothetical protein -
F4V16_RS24055 86215..86481 - 267 WP_000955263.1 hypothetical protein -
F4V16_RS24060 86481..86705 - 225 WP_001302623.1 hypothetical protein -
F4V16_RS24065 86829..87506 + 678 WP_001682408.1 IS66-like element accessory protein TnpA -
F4V16_RS24070 87506..87853 + 348 WP_000624622.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101684 101684


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T140429 WP_000970007.1 NZ_CP044183:83979-84260 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T140429 NZ_CP059180:c811944-811756 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT140429 WP_000079941.1 NZ_CP044183:83713-83982 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT140429 NZ_CP059180:c812233-811973 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References