Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2277..2802 Replicon plasmid pAR-0404-2
Accession NZ_CP044183
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain AR-0404

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag F4V16_RS23505 Protein ID WP_001159871.1
Coordinates 2497..2802 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag F4V16_RS23500 Protein ID WP_000813630.1
Coordinates 2277..2495 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V16_RS23485 494..748 - 255 WP_000678527.1 hypothetical protein -
F4V16_RS23490 793..1719 - 927 WP_001290416.1 hypothetical protein -
F4V16_RS23500 2277..2495 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
F4V16_RS23505 2497..2802 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
F4V16_RS23510 2803..3609 + 807 WP_000016969.1 site-specific integrase -
F4V16_RS23515 3789..4433 + 645 WP_001144036.1 ParA family protein -
F4V16_RS23520 4520..4828 + 309 WP_000030199.1 hypothetical protein -
F4V16_RS23525 5242..6222 + 981 WP_000688514.1 plasmid segregation protein ParM -
F4V16_RS23530 6215..6631 + 417 WP_001278818.1 plasmid partitioning/stability family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..101684 101684


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(29-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 13091.77 Da        Isoelectric Point: 12.8043

>T140428 WP_001159871.1 NZ_CP044183:2497-2802 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKKKKKKKK

Download         Length: 306 bp

>T140428 NZ_CP059170:c18375-18109 [Lactiplantibacillus plantarum]
ATGAGTAGTTATCAAGTTGAAATTAAGAATTCTGCTAAAAGTGATCTGAAAAAGTTAAAGAAATCGAACCTAAAAGCGCA
ATTTTTAAAAACAGTTGCTATTCTAAAAGAAAATCCTTACCAGCCAACACAATCATTTGAAAAGTTACAGCCAACTAGTC
GCGGATTATATTCAAGGCGATTAAATGCGCAGCACCGAGTAGTTTATCGAGTAGATGAAGAACTAAAAAAGGTCTACATT
TATGCCGCATGGAGTCATTACGAATAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 9374.72 Da        Isoelectric Point: 12.6573

>AT140428 WP_000813630.1 NZ_CP044183:2277-2495 [Salmonella enterica subsp. enterica serovar Heidelberg]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Download         Length: 219 bp

>AT140428 NZ_CP059170:c18635-18372 [Lactiplantibacillus plantarum]
ATGGAAAACTATACACCAACTAAAGCACGACAGAATCTTTACCAGATTTTGAAAGATATTAACCAGCAAAAAAAGCCGGT
TACAATCACGCCGGCTAATGGAGACGAGGACCAGGCAGCGATTATTATTTCTAAAAAAGATTGGGACTCAATCGCTGAAA
CCTTATACTTGGAAAATACCGGAACATTGGCTAAAGTCCGTGAACGTGAAGATGATGAGAGTGGCTTTACTAACGTTGAT
GACCTTGATTGGGATAATCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References