Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 24116..24638 Replicon plasmid pAR-0404-1
Accession NZ_CP044182
Organism Salmonella enterica subsp. enterica serovar Heidelberg strain AR-0404

Toxin (Protein)


Gene name relE Uniprot ID G3CAN5
Locus tag F4V16_RS23395 Protein ID WP_000220560.1
Coordinates 24116..24397 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag F4V16_RS23400 Protein ID WP_000121743.1
Coordinates 24387..24638 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V16_RS23350 19965..21131 - 1167 WP_000539532.1 relaxase/mobilization nuclease domain-containing protein -
F4V16_RS23355 21134..21679 - 546 WP_000757693.1 hypothetical protein -
F4V16_RS24265 21674..21748 - 75 Protein_23 DNA distortion polypeptide 3 -
F4V16_RS23360 22005..22277 - 273 WP_000160399.1 hypothetical protein -
F4V16_RS23365 22290..22487 - 198 WP_001675595.1 hypothetical protein -
F4V16_RS23370 22509..22688 - 180 WP_000439078.1 hypothetical protein -
F4V16_RS23375 22730..23059 - 330 WP_000866646.1 hypothetical protein -
F4V16_RS23380 23152..23367 - 216 WP_001180116.1 hypothetical protein -
F4V16_RS23385 23357..23602 - 246 WP_000356547.1 hypothetical protein -
F4V16_RS23390 23647..23970 - 324 WP_001181903.1 hypothetical protein -
F4V16_RS23395 24116..24397 - 282 WP_000220560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V16_RS23400 24387..24638 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
F4V16_RS23410 25872..26708 + 837 WP_001050931.1 replication initiation protein -
F4V16_RS23415 26748..27194 + 447 WP_001074386.1 hypothetical protein -
F4V16_RS23420 27262..27687 + 426 WP_000202944.1 hypothetical protein -
F4V16_RS23425 27684..28661 - 978 WP_001269910.1 hypothetical protein -
F4V16_RS23430 28686..28967 - 282 WP_001185482.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37696 37696


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(5-50)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T140427 WP_000220560.1 NZ_CP044182:c24397-24116 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T140427 NZ_CP059165:c5321648-5321175 [Mycobacterium vicinigordonae]
ATGGCCAAACTGTCTGGAGCTATCGACGTCCCATTGCCGCCGGAAAAGGCCTGGCAGCACGCCTCGGATCTGACCCGGTA
CAAGGAGTGGCTGACCATCCACAAGGTCTGGCGCAGCACTTTGCCCGACGTCATCGAGAAGGGCACGGTGCTGGAGTCCT
ATGTCGAGGTCAAGGGCATGACGAACCGCATTAAGTGGACGATCGTTCGGTACAAGCCGCCGGAGGGCATGACCCTCAAC
GGCGACGGAGTCGGCGGGGTGAAGGTGAAGCTGATCGCCAAGGTGTCGCCCAAGGACGACGGATCGGTGGTCGGCTTCGA
CGTCCACCTCGGCGGGCCGGCGCTGTTCGGTCCCATCGGGATGGTGGTGGCCGCCGCGCTGCGCAGCGATATCCGCGAGT
CGCTGCAGAACTTCGTCAGGGTGTTTGTCCGCCCCGATCCCGGCACGATCGGCGACAGCGTCCTGCATCGCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>AT140427 WP_000121743.1 NZ_CP044182:c24638-24387 [Salmonella enterica subsp. enterica serovar Heidelberg]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>AT140427 NZ_CP059165:c5321834-5321655 [Mycobacterium vicinigordonae]
ATGGGCTTTCTGAATAAGGCCAAAGACCTGCTGGCGCAGAACTCTGACAAGGTCGAGACGGCGATCAATAAGGCCGGCGA
ATTCGTCGACGAGAAGACGCAGCATAAATACTCCGACGCCATCCACAAGGTGCAGGAGGAAGCCAAGAAGGTCGCCGCAC
CGGGCGACCAGCAGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G3CAN5

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References