Detailed information of TA system TA140426

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 6938..7856
• Replicon: plasmid pAR-0413-2
• Accession: NZ_CP044172
• Organism: Campylobacter jejuni strain AR-0413

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: F4V25_RS08995
• Protein ID: WP_002907829.1
• Coordinates: 6938..7621 (-)
• Length: 228 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: A0A3Z9GMV3
• Locus tag: F4V25_RS09000
• Protein ID: WP_002907823.1
• Coordinates: 7614..7856 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F4V25_RS08950	2816..3040	-	225	WP_057099614.1	hypothetical protein	-
F4V25_RS08955	3043..3729	-	687	WP_002907859.1	AAA family ATPase	-
F4V25_RS08960	3810..4205	-	396	WP_002907857.1	conjugal transfer protein TraM	-
F4V25_RS08965	4206..4748	-	543	WP_002907846.1	hypothetical protein	-
F4V25_RS08970	4745..5248	-	504	WP_002907844.1	hypothetical protein	-
F4V25_RS08975	5245..5640	-	396	WP_002907843.1	hypothetical protein	-
F4V25_RS08980	5637..5960	-	324	WP_002907841.1	hypothetical protein	-
F4V25_RS08985	5970..6377	-	408	WP_002907839.1	hypothetical protein	-
F4V25_RS08990	6466..6933	-	468	WP_002907837.1	signal peptidase I	-
F4V25_RS08995	6938..7621	-	684	WP_002907829.1	Fic family protein	Toxin
F4V25_RS09000	7614..7856	-	243	WP_002907823.1	hypothetical protein	Antitoxin
F4V25_RS09005	7948..8667	-	720	WP_002907820.1	conjugal transfer protein TraL	-
F4V25_RS09010	8684..10507	-	1824	WP_002907817.1	type IV secretory system conjugative DNA transfer family protein	-
F4V25_RS09015	10504..12717	-	2214	WP_002907814.1	DUF1738 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..25131	25131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (60-169)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 228 a.a.
• Molecular weight: 26164.33 Da
• Isoelectric Point: 10.0750

>T140426 WP_002907829.1 NZ_CP044172:c7621-6938 [Campylobacter jejuni]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIYACAEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGISL

Nucleotide

• Length: 684 bp

>T140426 NZ_CP059162:2958335-2958616 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTTCCGGCCGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AACTGCGCACAGCGGGCTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGCCATTGCCGTGGGCAAG
CGGGAGCGGGGGAGTGTCTATCAGCAAGCCAGGAAGCGTTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9276.49 Da
• Isoelectric Point: 4.3697

>AT140426 WP_002907823.1 NZ_CP044172:c7856-7614 [Campylobacter jejuni]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEGIKSVICGHAIEDMFANEKDVIDMIKIAKDEANADEIIAEYKREWGVND

Nucleotide

• Length: 243 bp

>AT140426 NZ_CP059162:2958097-2958345 [Pseudomonas chlororaphis subsp. aurantiaca]
ATGACCCATGTCCTTCTGTCCAACGTCGTCGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATTCTCAATCGCAACGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCCATGA
TGGAGCGTCTGGAGGATATGGAGCTGCTCGCCTTGTGCCGTGAGCGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A3Z9GMV3