Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4443128..4443654 | Replicon | chromosome |
| Accession | NZ_CP044155 | ||
| Organism | Shigella flexneri strain AR-0424 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | F4V36_RS22615 | Protein ID | WP_000323025.1 |
| Coordinates | 4443128..4443415 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | F4V36_RS22620 | Protein ID | WP_000534858.1 |
| Coordinates | 4443415..4443654 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| F4V36_RS22560 (4438186) | 4438186..4438521 | + | 336 | WP_000871291.1 | anti-adapter protein IraM | - |
| F4V36_RS22565 (4438802) | 4438802..4438910 | - | 109 | Protein_4322 | DUF3927 family protein | - |
| F4V36_RS22585 (4439831) | 4439831..4440652 | - | 822 | WP_000762882.1 | antitermination protein | - |
| F4V36_RS22590 (4440667) | 4440667..4441023 | - | 357 | WP_000904111.1 | RusA family crossover junction endodeoxyribonuclease | - |
| F4V36_RS22595 (4441036) | 4441036..4442085 | - | 1050 | WP_001265249.1 | DUF968 domain-containing protein | - |
| F4V36_RS22600 (4442087) | 4442087..4442365 | - | 279 | Protein_4326 | hypothetical protein | - |
| F4V36_RS22605 (4442432) | 4442432..4442683 | - | 252 | WP_000980987.1 | protein Rem | - |
| F4V36_RS22610 (4442901) | 4442901..4443056 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| F4V36_RS22615 (4443128) | 4443128..4443415 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| F4V36_RS22620 (4443415) | 4443415..4443654 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| F4V36_RS22625 (4443679) | 4443679..4443984 | + | 306 | WP_071818640.1 | hypothetical protein | - |
| F4V36_RS22630 (4443981) | 4443981..4445137 | - | 1157 | Protein_4332 | IS3 family transposase | - |
| F4V36_RS22635 (4445199) | 4445199..4446218 | + | 1020 | Protein_4333 | MHS family MFS transporter YdfJ | - |
| F4V36_RS22640 (4446307) | 4446307..4447767 | + | 1461 | WP_000527804.1 | mannitol dehydrogenase family protein | - |
| F4V36_RS22645 (4447803) | 4447803..4448006 | - | 204 | WP_000214712.1 | putative selenium delivery protein YdfZ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4432215..4451886 | 19671 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T140384 WP_000323025.1 NZ_CP044155:c4443415-4443128 [Shigella flexneri]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T140384 NZ_CP059130:c4015368-4014961 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT140384 WP_000534858.1 NZ_CP044155:c4443654-4443415 [Shigella flexneri]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT140384 NZ_CP059130:c4015615-4015349 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATATGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATATGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|