Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4205284..4205902 Replicon chromosome
Accession NZ_CP044151
Organism Shigella sonnei strain AR-0426

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag F4V38_RS21635 Protein ID WP_001291435.1
Coordinates 4205284..4205502 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag F4V38_RS21640 Protein ID WP_000344800.1
Coordinates 4205528..4205902 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V38_RS21600 (4200576) 4200576..4201148 + 573 WP_000779812.1 YbaY family lipoprotein -
F4V38_RS21605 (4201179) 4201179..4201490 - 312 WP_167553807.1 MGMT family protein -
F4V38_RS21615 (4201869) 4201869..4202222 + 354 WP_000878140.1 DUF1428 domain-containing protein -
F4V38_RS21620 (4202264) 4202264..4203812 - 1549 Protein_4180 cyclic-guanylate-specific phosphodiesterase PdeB -
F4V38_RS21625 (4203976) 4203976..4204446 - 471 WP_000136192.1 YlaC family protein -
F4V38_RS21630 (4204562) 4204562..4205113 - 552 WP_000102564.1 maltose O-acetyltransferase -
F4V38_RS21635 (4205284) 4205284..4205502 - 219 WP_001291435.1 HHA domain-containing protein Toxin
F4V38_RS21640 (4205528) 4205528..4205902 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
F4V38_RS21645 (4206448) 4206448..4209597 - 3150 WP_001132464.1 efflux RND transporter permease AcrB -
F4V38_RS21650 (4209620) 4209620..4210813 - 1194 WP_011310152.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T140337 WP_001291435.1 NZ_CP044151:c4205502-4205284 [Shigella sonnei]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T140337 NZ_CP059119:c3860118-3859720 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT140337 WP_000344800.1 NZ_CP044151:c4205902-4205528 [Shigella sonnei]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT140337 NZ_CP059119:c3860414-3860121 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References