Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2681493..2682121 Replicon chromosome
Accession NZ_CP044151
Organism Shigella sonnei strain AR-0426

Toxin (Protein)


Gene name hicA Uniprot ID A0A827WKV6
Locus tag F4V38_RS14135 Protein ID WP_001259380.1
Coordinates 2681849..2682121 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag F4V38_RS14130 Protein ID WP_000593555.1
Coordinates 2681493..2681852 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V38_RS14105 (2677625) 2677625..2678569 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
F4V38_RS14110 (2678566) 2678566..2679399 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
F4V38_RS14115 (2679399) 2679399..2680163 + 765 WP_001136223.1 nickel import ATP-binding protein NikD -
F4V38_RS14120 (2680160) 2680160..2680966 + 807 WP_000173703.1 nickel import ATP-binding protein NikE -
F4V38_RS14125 (2680972) 2680972..2681373 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
F4V38_RS14130 (2681493) 2681493..2681852 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
F4V38_RS14135 (2681849) 2681849..2682121 - 273 WP_001259380.1 type II toxin-antitoxin system HicA family toxin Toxin
F4V38_RS14140 (2682194) 2682194..2683318 - 1125 WP_005140446.1 ABC transporter permease -
F4V38_RS14145 (2683318) 2683318..2686053 - 2736 WP_000149089.1 ribosome-associated ATPase/putative transporter RbbA -
F4V38_RS14150 (2686050) 2686050..2687117 - 1068 WP_000361520.1 HlyD family secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(29-79)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10071.81 Da        Isoelectric Point: 10.7076

>T140333 WP_001259380.1 NZ_CP044151:c2682121-2681849 [Shigella sonnei]
MRTKVQALRKKKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVR
DWLLSIGVKP

Download         Length: 273 bp

>T140333 NZ_CP059119:c2529426-2529250 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT140333 WP_000593555.1 NZ_CP044151:c2681852-2681493 [Shigella sonnei]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT140333 NZ_CP059119:c2529204-2528788 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A827WKV6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References