Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 614327..614811 Replicon chromosome
Accession NZ_CP044151
Organism Shigella sonnei strain AR-0426

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A377EAU1
Locus tag F4V38_RS03300 Protein ID WP_014334020.1
Coordinates 614521..614811 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID A0A376K4R9
Locus tag F4V38_RS03295 Protein ID WP_005142544.1
Coordinates 614327..614521 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V38_RS03255 (609523) 609523..609879 - 357 WP_005140877.1 hypothetical protein -
F4V38_RS03260 (609937) 609937..610359 - 423 WP_001151171.1 DUF977 family protein -
F4V38_RS03265 (610375) 610375..611100 - 726 WP_000450631.1 DUF1627 domain-containing protein -
F4V38_RS03270 (611122) 611122..611868 - 747 WP_000788740.1 ATP-binding protein -
F4V38_RS03275 (611875) 611875..612939 - 1065 WP_001262380.1 hypothetical protein -
F4V38_RS03280 (613011) 613011..613436 - 426 WP_000693826.1 toxin YdaT family protein -
F4V38_RS03285 (613433) 613433..613696 - 264 WP_001048456.1 helix-turn-helix transcriptional regulator -
F4V38_RS03290 (613871) 613871..614281 + 411 WP_252997169.1 helix-turn-helix domain-containing protein -
F4V38_RS03295 (614327) 614327..614521 + 195 WP_005142544.1 hypothetical protein Antitoxin
F4V38_RS03300 (614521) 614521..614811 + 291 WP_014334020.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V38_RS03305 (615090) 615090..615242 + 153 WP_000379558.1 DUF1391 family protein -
F4V38_RS03310 (615254) 615254..615619 + 366 WP_024174355.1 hypothetical protein -
F4V38_RS03320 (616521) 616521..616616 + 96 Protein_648 transcriptional regulator -
F4V38_RS03325 (616627) 616627..616815 + 189 WP_000449206.1 cell division inhibition protein DicB -
F4V38_RS03330 (616812) 616812..617003 + 192 WP_001090204.1 DUF1482 family protein -
F4V38_RS03335 (617097) 617097..618155 + 1059 Protein_651 exonuclease -
F4V38_RS03345 (619420) 619420..619662 + 243 Protein_653 benzoate/H(+) symporter BenE family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 605528..626689 21161


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11062.93 Da        Isoelectric Point: 10.2013

>T140327 WP_014334020.1 NZ_CP044151:614521-614811 [Shigella sonnei]
MLPVLWLPSARDDLRQIVAYIAKENPAAARRMKIRIETSVLPLTEHPYLYPPSERVLGLREIVTHPNYIILYRVTASSIE
VVNIVHSRRQYPGKNS

Download         Length: 291 bp

>T140327 NZ_CP059119:c1045163-1044756 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 7097.98 Da        Isoelectric Point: 4.1759

>AT140327 WP_005142544.1 NZ_CP044151:614327-614521 [Shigella sonnei]
MSTVLSPMVSEFETVEQENSYNEWLRAKVAASLADPRPAIPHDEVMAEMEQIIAQIAAATHRGE

Download         Length: 195 bp

>AT140327 NZ_CP059119:c1045410-1045144 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A377EAU1

Antitoxin

Source ID Structure
AlphaFold DB A0A376K4R9

References