Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 4745377..4746082 Replicon chromosome
Accession NZ_CP044148
Organism Escherichia coli O157 strain AR-0427

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag F4V39_RS23750 Protein ID WP_000539519.1
Coordinates 4745696..4746082 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F4V39_RS23745 Protein ID WP_001280945.1
Coordinates 4745377..4745706 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V39_RS23730 4740534..4741445 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
F4V39_RS23735 4741623..4743971 + 2349 WP_000950320.1 EAL domain-containing protein -
F4V39_RS23740 4743979..4745307 + 1329 WP_000086905.1 GGDEF domain-containing protein -
F4V39_RS23745 4745377..4745706 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
F4V39_RS23750 4745696..4746082 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V39_RS23755 4746308..4747633 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
F4V39_RS23760 4747846..4748229 + 384 WP_000497137.1 biofilm formation regulator BssR -
F4V39_RS23765 4748340..4749455 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
F4V39_RS23770 4749452..4750078 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T140306 WP_000539519.1 NZ_CP044148:c4746082-4745696 [Escherichia coli O157]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T140306 NZ_CP059087:79248-79562 [Pantoea agglomerans]
ATGCAGTTCACTGTATACAGTAATACTGGGAAAAGCGCCGTCTATCCCCTGCTGCTCGATGTTACCAGCGATATTATCGG
GCAGTTGAACCGCAGGATTGTGATCCCCTTGCTGCCTCTTGAAAAGTACCCGAGCAGCACGCGACCTGAACGGCTGGTTC
CGCTTATCAGACTGACTGATGACAAAGAATATGCCGTAATGACGCATGAAATGGCGAGCATTCCCACTCGTGCTTTGGGG
GCTGTGTTCTGCGATTCATCTCTCTATCGTACAGAGATTAAAGCTGCTATTGATTTTCTTCTCGACGGTATCTAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT140306 WP_001280945.1 NZ_CP044148:c4745706-4745377 [Escherichia coli O157]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT140306 NZ_CP059087:79009-79245 [Pantoea agglomerans]
ATGGCTATAACACAACGAGCAACGCAAAGCGTTACCATGACCGTAGAACGTGACTTACTCAGCCGTGCGCGTGAGGCCGG
AATTAATCTCAGTGCTACCCTGACCACGGCCCTCGACGCTGAACTTCGTCAGTACGAGGCAAAAAAATGGCAGGAGGAAA
ACAGCGAAGCACTGGAAGCTCTAAACCGCTTTCACGATGAACACGGTTGTTTCAGCGATGAGTACAGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References