Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 4290647..4291265 | Replicon | chromosome |
Accession | NZ_CP044148 | ||
Organism | Escherichia coli O157 strain AR-0427 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | H5UYE2 |
Locus tag | F4V39_RS21605 | Protein ID | WP_001291435.1 |
Coordinates | 4290647..4290865 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | S1PTH5 |
Locus tag | F4V39_RS21610 | Protein ID | WP_000344800.1 |
Coordinates | 4290891..4291265 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F4V39_RS21570 | 4285934..4286506 | + | 573 | WP_000779831.1 | YbaY family lipoprotein | - |
F4V39_RS21575 | 4286539..4286850 | - | 312 | WP_000409911.1 | MGMT family protein | - |
F4V39_RS21585 | 4287229..4287582 | + | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
F4V39_RS21590 | 4287624..4289174 | - | 1551 | WP_001301851.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
F4V39_RS21595 | 4289338..4289808 | - | 471 | WP_000136192.1 | YlaC family protein | - |
F4V39_RS21600 | 4289924..4290475 | - | 552 | WP_000102553.1 | maltose O-acetyltransferase | - |
F4V39_RS21605 | 4290647..4290865 | - | 219 | WP_001291435.1 | hemolysin expression modulator Hha | Toxin |
F4V39_RS21610 | 4290891..4291265 | - | 375 | WP_000344800.1 | Hha toxicity modulator TomB | Antitoxin |
F4V39_RS21615 | 4291811..4294960 | - | 3150 | WP_001132452.1 | multidrug efflux RND transporter permease subunit | - |
F4V39_RS21620 | 4294983..4296176 | - | 1194 | WP_001295324.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T140305 WP_001291435.1 NZ_CP044148:c4290865-4290647 [Escherichia coli O157]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T140305 NZ_CP059084:3387676-3387891 [Pantoea ananatis]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGTTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGTTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTACCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTATGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14557.39 Da Isoelectric Point: 4.7395
>AT140305 WP_000344800.1 NZ_CP044148:c4291265-4290891 [Escherichia coli O157]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT140305 NZ_CP059084:3387274-3387651 [Pantoea ananatis]
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG
ATGGACGAATACTCACCGAAACGGCATGATATTGCCCAGCTTAAATACTTGTGTGAGAATCTGTTTGACGACAGCATGGC
GACATTAACTGACAGTCATCACGGCTGGGTTAATGACCCCACTGCCGAAAGCAATTTACAGCTAAACGATTTGATTGAGC
ACATCGCCTCTTTCACCATGAATTACAAAATTAAGCACGTTGAAGACGAAGCACTGATTACCCAAATCGATGAATATCTT
GATGATACCTTTATGCTGTTTAGCAACTACAGTGTAAATACTCAGGATCTTCAGCGCTGGCAACGCTCAGCGAAACGTTT
ATTTAATGTGTTTACTGAAGAGTGCGCTTTTCTTCAACAGCCAAGCCATTCATTATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
PDB | 2MW2 | |
PDB | 1JW2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9QBQ5 |