Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ataRT/DUF1778(antitoxin) |
Location | 2523669..2524423 | Replicon | chromosome |
Accession | NZ_CP044148 | ||
Organism | Escherichia coli O157 strain AR-0427 |
Toxin (Protein)
Gene name | ataT | Uniprot ID | - |
Locus tag | F4V39_RS13280 | Protein ID | WP_001301452.1 |
Coordinates | 2523938..2524423 (+) | Length | 162 a.a. |
Antitoxin (Protein)
Gene name | ataR | Uniprot ID | Q8X700 |
Locus tag | F4V39_RS13275 | Protein ID | WP_000801912.1 |
Coordinates | 2523669..2523947 (+) | Length | 93 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
F4V39_RS13270 | 2520897..2523602 | + | 2706 | WP_000906970.1 | HTH-type transcriptional regulator MalT | - |
F4V39_RS13275 | 2523669..2523947 | + | 279 | WP_000801912.1 | DUF1778 domain-containing protein | Antitoxin |
F4V39_RS13280 | 2523938..2524423 | + | 486 | WP_001301452.1 | GNAT family N-acetyltransferase | Toxin |
F4V39_RS13285 | 2524473..2525501 | - | 1029 | WP_000827117.1 | RNA 3'-terminal phosphate cyclase | - |
F4V39_RS13290 | 2525505..2526731 | - | 1227 | WP_001105473.1 | RNA-splicing ligase RtcB | - |
F4V39_RS13295 | 2526919..2528517 | + | 1599 | WP_001232889.1 | DNA-binding transcriptional regulator RtcR | - |
F4V39_RS13300 | 2528499..2529257 | - | 759 | WP_001302007.1 | DeoR/GlpR family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17650.57 Da Isoelectric Point: 9.4066
>T140290 WP_001301452.1 NZ_CP044148:2523938-2524423 [Escherichia coli O157]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E
Download Length: 486 bp
>T140290 NZ_CP059082:2796874-2797392 [Halomonas titanicae]
ATGATAGTGCTGCCGGAGCTGAAAACTCAGGCATACCGTGTACATGTTCCGCGCTGGGCATTTTCGCCTACTAGTGGGGC
CGGAGCGAGAGAGCATGGAGGAAGGCTAAACCGAGTTGGTGTAGATGCATTATACCTGTCGCTAGAGGAGCAAACGGCGT
TAGCGGAGTACAAGCAGCTTTCTGCATTAATGCCACCTGGACTGATTGTTAGCTATACGGTCAGCGTGACGACTATTGTC
GATTTTCGATCAGGTTATAACTCGAAATGGGATAGCCTTTGGCAAGAGCTTAACTGTGACTGGCGTAAGTATTGGTTTAA
TCAGCGCATTGAGCCGCCTAGCTGGATATTAGGCGATATGGCGTTGGAGCAGGGGGCCAAGGGGATACTTTTTCCTTCGT
TGGCAAGAGACTCAGGCACCAACCTCGTTCTCTATACCGAAACGTTAACAGAAAACGATATGCTCGAGGTTTATGATCCC
AAAGGTGATTTGCCGCACAACGCGCGCTCTTGGCAGTAA
ATGATAGTGCTGCCGGAGCTGAAAACTCAGGCATACCGTGTACATGTTCCGCGCTGGGCATTTTCGCCTACTAGTGGGGC
CGGAGCGAGAGAGCATGGAGGAAGGCTAAACCGAGTTGGTGTAGATGCATTATACCTGTCGCTAGAGGAGCAAACGGCGT
TAGCGGAGTACAAGCAGCTTTCTGCATTAATGCCACCTGGACTGATTGTTAGCTATACGGTCAGCGTGACGACTATTGTC
GATTTTCGATCAGGTTATAACTCGAAATGGGATAGCCTTTGGCAAGAGCTTAACTGTGACTGGCGTAAGTATTGGTTTAA
TCAGCGCATTGAGCCGCCTAGCTGGATATTAGGCGATATGGCGTTGGAGCAGGGGGCCAAGGGGATACTTTTTCCTTCGT
TGGCAAGAGACTCAGGCACCAACCTCGTTCTCTATACCGAAACGTTAACAGAAAACGATATGCTCGAGGTTTATGATCCC
AAAGGTGATTTGCCGCACAACGCGCGCTCTTGGCAGTAA
Antitoxin
Download Length: 93 a.a. Molecular weight: 10420.94 Da Isoelectric Point: 4.6336
>AT140290 WP_000801912.1 NZ_CP044148:2523669-2523947 [Escherichia coli O157]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE
Download Length: 279 bp
>AT140290 NZ_CP059082:2796446-2796877 [Halomonas titanicae]
ATGGCAATTGACACTGTAAAAGAATCCCTTAATGAGTCATCCGGGTATTTGGTTCCTGATTCATTCGAGCGGTTTTTAGC
TGATTTGAAGGGAGCTGCTCGTAAAGATCGCCACCCATTGATTAACCCGAAGTTGTTTGCCAGTGCATTGAGCATTGATA
TCCAAACGCTGGCCAACCAAGCACATGTTCATCGTACGACGATATCCCGTGCTCAGGGAGCGGAAAAACTTCAACGTTAT
CTTCGTGATGCACTTCGTGTGCTCGGCGCAGCGGCGGATATTAATGGTGACTTTCATGACGCTCTGTTTTGGTTTCGCAA
CGAGCCGCTTAGCGCATTTGACTATAAAACACCCGAGCAACTCGTAAGTGAAGGGCGCGCAGAAGACTTGTTGCGCTATG
TTCAGGCGCTACAAGCAGGTGTAGTGGGATGA
ATGGCAATTGACACTGTAAAAGAATCCCTTAATGAGTCATCCGGGTATTTGGTTCCTGATTCATTCGAGCGGTTTTTAGC
TGATTTGAAGGGAGCTGCTCGTAAAGATCGCCACCCATTGATTAACCCGAAGTTGTTTGCCAGTGCATTGAGCATTGATA
TCCAAACGCTGGCCAACCAAGCACATGTTCATCGTACGACGATATCCCGTGCTCAGGGAGCGGAAAAACTTCAACGTTAT
CTTCGTGATGCACTTCGTGTGCTCGGCGCAGCGGCGGATATTAATGGTGACTTTCATGACGCTCTGTTTTGGTTTCGCAA
CGAGCCGCTTAGCGCATTTGACTATAAAACACCCGAGCAACTCGTAAGTGAAGGGCGCGCAGAAGACTTGTTGCGCTATG
TTCAGGCGCTACAAGCAGGTGTAGTGGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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