Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 2523669..2524423 Replicon chromosome
Accession NZ_CP044148
Organism Escherichia coli O157 strain AR-0427

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag F4V39_RS13280 Protein ID WP_001301452.1
Coordinates 2523938..2524423 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag F4V39_RS13275 Protein ID WP_000801912.1
Coordinates 2523669..2523947 (+) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V39_RS13270 2520897..2523602 + 2706 WP_000906970.1 HTH-type transcriptional regulator MalT -
F4V39_RS13275 2523669..2523947 + 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
F4V39_RS13280 2523938..2524423 + 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
F4V39_RS13285 2524473..2525501 - 1029 WP_000827117.1 RNA 3'-terminal phosphate cyclase -
F4V39_RS13290 2525505..2526731 - 1227 WP_001105473.1 RNA-splicing ligase RtcB -
F4V39_RS13295 2526919..2528517 + 1599 WP_001232889.1 DNA-binding transcriptional regulator RtcR -
F4V39_RS13300 2528499..2529257 - 759 WP_001302007.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(45-143)

Antitoxin

(2-92)


Sequences


Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T140290 WP_001301452.1 NZ_CP044148:2523938-2524423 [Escherichia coli O157]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T140290 NZ_CP059082:2796874-2797392 [Halomonas titanicae]
ATGATAGTGCTGCCGGAGCTGAAAACTCAGGCATACCGTGTACATGTTCCGCGCTGGGCATTTTCGCCTACTAGTGGGGC
CGGAGCGAGAGAGCATGGAGGAAGGCTAAACCGAGTTGGTGTAGATGCATTATACCTGTCGCTAGAGGAGCAAACGGCGT
TAGCGGAGTACAAGCAGCTTTCTGCATTAATGCCACCTGGACTGATTGTTAGCTATACGGTCAGCGTGACGACTATTGTC
GATTTTCGATCAGGTTATAACTCGAAATGGGATAGCCTTTGGCAAGAGCTTAACTGTGACTGGCGTAAGTATTGGTTTAA
TCAGCGCATTGAGCCGCCTAGCTGGATATTAGGCGATATGGCGTTGGAGCAGGGGGCCAAGGGGATACTTTTTCCTTCGT
TGGCAAGAGACTCAGGCACCAACCTCGTTCTCTATACCGAAACGTTAACAGAAAACGATATGCTCGAGGTTTATGATCCC
AAAGGTGATTTGCCGCACAACGCGCGCTCTTGGCAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT140290 WP_000801912.1 NZ_CP044148:2523669-2523947 [Escherichia coli O157]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp

>AT140290 NZ_CP059082:2796446-2796877 [Halomonas titanicae]
ATGGCAATTGACACTGTAAAAGAATCCCTTAATGAGTCATCCGGGTATTTGGTTCCTGATTCATTCGAGCGGTTTTTAGC
TGATTTGAAGGGAGCTGCTCGTAAAGATCGCCACCCATTGATTAACCCGAAGTTGTTTGCCAGTGCATTGAGCATTGATA
TCCAAACGCTGGCCAACCAAGCACATGTTCATCGTACGACGATATCCCGTGCTCAGGGAGCGGAAAAACTTCAACGTTAT
CTTCGTGATGCACTTCGTGTGCTCGGCGCAGCGGCGGATATTAATGGTGACTTTCATGACGCTCTGTTTTGGTTTCGCAA
CGAGCCGCTTAGCGCATTTGACTATAAAACACCCGAGCAACTCGTAAGTGAAGGGCGCGCAGAAGACTTGTTGCGCTATG
TTCAGGCGCTACAAGCAGGTGTAGTGGGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References