140287

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2035588..2036242 Replicon chromosome
Accession NZ_CP044148
Organism Escherichia coli O157 strain AR-0427

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag F4V39_RS10735 Protein ID WP_000244781.1
Coordinates 2035588..2035995 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag F4V39_RS10740 Protein ID WP_000354046.1
Coordinates 2035976..2036242 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V39_RS10715 2031545..2033278 - 1734 WP_000813186.1 single-stranded-DNA-specific exonuclease RecJ -
F4V39_RS10720 2033284..2033994 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F4V39_RS10725 2034019..2034915 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
F4V39_RS10730 2035027..2035548 + 522 WP_001055874.1 flavodoxin FldB -
F4V39_RS10735 2035588..2035995 - 408 WP_000244781.1 protein YgfX Toxin
F4V39_RS10740 2035976..2036242 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
F4V39_RS10745 2036485..2037465 + 981 WP_000886053.1 tRNA-modifying protein YgfZ -
F4V39_RS10750 2037542..2038201 - 660 WP_000250274.1 hemolysin III family protein -
F4V39_RS10755 2038365..2038676 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
F4V39_RS10760 2038721..2040154 + 1434 WP_001310226.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T140287 WP_000244781.1 NZ_CP044148:c2035995-2035588 [Escherichia coli O157]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T140287 NZ_CP059082:c1332618-1332154 [Halomonas titanicae]
ATGAGCGAGGTCACCGCCTATCGGCTGGTTAAGCGTAAGTTTCAGGAGACAGCGTTTGATGGCGAAGGCGCACGGCTTTA
CGGTGGGCGCTGGAACAGCCCAGGGAATGCCTGTGTGTATGTGGCAAGCTACGAGTCGCTGGCACTACTGGAAATTATGG
TGAATCTGGAAAGCTATCGGCTGCTCAATGCGTATGCGCTGCTGCGCCTGACGCTACCAGCCGACAGTATTCTAAGCATT
GGCGCAGAAGATCTACCAGAAAACTGGCAGGAAGCCCCAGCGCCCGCAGAGACCGCTGAACTTGGCGATGGCTGGCTGGC
CTCAGGCCAAAGTCTGGCACTGGCAGTGCCAAGCGTGGTCGTGCCGAGAGAGCTCAACTACATGCTCAACCCGGCACACC
CCTTATTCGATCAAATCGTCGCGACAGCCGAGGCACTGCCATTTCAACCCGATCCAAGACTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT140287 WP_000354046.1 NZ_CP044148:c2036242-2035976 [Escherichia coli O157]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT140287 NZ_CP059082:c1333064-1332615 [Halomonas titanicae]
ATGGATATCCACTTCACTCAATACCAGCCACCCAAAGCTTTGGCGTCCGGTTTCTGGCAACAAATTGGCTTGCCAGCCAG
AGGCCGCAAGTTGCATGAGCTGTTGCATGAAGGGGTGGAGTATCGTGTTTATCCCCAGATTGCCAAGGTATCAGGTATTG
AGCAGAAGGCACTGGCGCGCTACGTGGATATTCCCTCTGCTACGCTTAGCCGTCGCGCCAAATCGGGCCGTTTCAAAATG
GCAGAGAGTGACCGGCTGTATCGCTTTGCTGAGCTTTTCAAGGCGGCACTGGATCTGTTCGAGGGGGACTCAGAGGGCGC
CCGCGCCTGGCTACTCAAACCCAATGCCGGGCTAGGCGGTCGTCGCCCTGTCGAAATGAGCGCCACATCGGCAGAGTATC
AAACGGTGTTGAATCTGATCGGGCGGCTGGAGCATGGTGTCTCGGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References