Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 877413..877891 Replicon chromosome
Accession NZ_CP044145
Organism Escherichia coli O157 strain AR-0428

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag F4V40_RS04190 Protein ID WP_001303876.1
Coordinates 877413..877700 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag F4V40_RS04195 Protein ID WP_000536233.1
Coordinates 877700..877891 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V40_RS04150 872562..875033 - 2472 WP_000034474.1 exonuclease -
F4V40_RS04155 875127..875318 - 192 WP_001098307.1 DUF1482 family protein -
F4V40_RS04160 875315..875503 - 189 WP_000413705.1 cell division inhibition protein DicB -
F4V40_RS04170 876077..876262 + 186 WP_001133046.1 hypothetical protein -
F4V40_RS04175 876449..876838 - 390 WP_000394511.1 hypothetical protein -
F4V40_RS04180 876980..877135 - 156 WP_000379575.1 DUF1391 family protein -
F4V40_RS04190 877413..877700 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V40_RS04195 877700..877891 - 192 WP_000536233.1 hypothetical protein Antitoxin
F4V40_RS04200 877919..878320 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
F4V40_RS04205 878429..878701 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
F4V40_RS04210 878685..879110 + 426 WP_000693855.1 Rha family transcriptional regulator -
F4V40_RS04215 879317..879772 - 456 WP_000273724.1 hypothetical protein -
F4V40_RS04220 879851..880942 + 1092 WP_001205823.1 hypothetical protein -
F4V40_RS04225 880949..881695 + 747 WP_000788751.1 ATP-binding protein -
F4V40_RS04230 881717..882487 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T140240 WP_001303876.1 NZ_CP044145:c877700-877413 [Escherichia coli O157]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T140240 NZ_CP059045:c3454351-3453935 [Cronobacter sakazakii]
GTGGTCCTGTGGCACTCTGATCTTCGCGTTTCATGGCGCTCGCAGTGGCTATCGCTGCTGCTGCACGGCGCCGTGGCCGT
TATTATTTTGCTGCTCCCCTGGCCGCTGCGGTATCTGCCCGTGTGGATGCTGTTGCTGTCTCTGGTGGTGTTTGACTGCG
TACGTAGCCAGCGGCGTATCAATGCGTTCCAGGGCGAGGTCAGCCTGACGGCTGATTATTACCTTCGCTGGCAGGGCGTT
GACTGGCAGATTTGCGCCACGCCCTGGATGCTGCGCAGCGGAATGATGCTGCGGCTGCGTCATCCTAAAACGACACGCCG
CCATCATGTCTGGCTGGCGGCGGATAGCATGACGGAAGCAGAGTGGCGCGATTTGCGTCGCCTTCTGTTGCAACAGCCCG
TAGGCGACAAACGCTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT140240 WP_000536233.1 NZ_CP044145:c877891-877700 [Escherichia coli O157]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT140240 NZ_CP059045:c3454598-3454332 [Cronobacter sakazakii]
ATGGATATTAATAATAAAGCCCGTATTCACTGGGCATGTCGCAGAGGTATGCGCGAGCTGGATATTTCCATCATGCCTTT
CTTTGAATATGACTATGACTCCCTGAGCGACGAAGACAAACGCGTTTTTGTCCGCCTGCTGGAGTGTGACGATCCTGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCAGCTGATGCGGAGCTGGCGCGAATGGTGGAATTAATCCAGCAGCGGAAT
CAGGCACGTGGTCCTGTGGCACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References