Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 711026..711731 Replicon chromosome
Accession NZ_CP044145
Organism Escherichia coli O157 strain AR-0428

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag F4V40_RS03415 Protein ID WP_000539519.1
Coordinates 711345..711731 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F4V40_RS03410 Protein ID WP_001280945.1
Coordinates 711026..711355 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V40_RS03395 706183..707094 + 912 WP_001236044.1 glutathione ABC transporter permease GsiD -
F4V40_RS03400 707272..709620 + 2349 WP_000950320.1 EAL domain-containing protein -
F4V40_RS03405 709628..710956 + 1329 WP_000086905.1 GGDEF domain-containing protein -
F4V40_RS03410 711026..711355 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
F4V40_RS03415 711345..711731 - 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F4V40_RS03420 711957..713282 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
F4V40_RS03425 713495..713878 + 384 WP_000497137.1 biofilm formation regulator BssR -
F4V40_RS03430 713989..715104 + 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
F4V40_RS03435 715101..715727 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T140239 WP_000539519.1 NZ_CP044145:c711731-711345 [Escherichia coli O157]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T140239 NZ_CP059045:c2845496-2845149 [Cronobacter sakazakii]
ATGTGGACTATTTACCTTACTCACGAGTTTGAGTGCTGGCTCGCGAGACAGCCGCAGCCGTTGCAGGAAGATGTGCTGAC
CGCGCTGGGGCTTTTGAAAATCAAAGGTCCGCACCTCGGGTGCCCGTATGCCGATACGCTCAAAGGCTCGCGCCAGGCGG
GTATGAAGGAATTACGGGTTCAGCACGCCGGGCGGTCCATACGCGCCTTTTACGCTTTTGATCCGCACCGTTACGCCATT
GTGCTGTGCGCGGCACAGAAAAAGGGCGATGAAAAGCGGTTTTACCGGGTCATACTGCGCGTCGCTGACAAACTGTTTAG
CCACTATCTGAACCACCGGGAGGTATAG

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT140239 WP_001280945.1 NZ_CP044145:c711355-711026 [Escherichia coli O157]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT140239 NZ_CP059045:c2845148-2844849 [Cronobacter sakazakii]
ATGAAGACGTTTGATGAAGTGCTGGCGGCGCAGACCCCGGAGGCCCGCGCGCGTATCGAAGAGAAAACGGCGCAGCTGCT
GCTGGAAACCCATCTGTATGCGCTGCGCGAGGCGCTCAGCGTGTCGCAAACCGAGATGGCGCGCCAGATGGGTATCGCCC
AGCCGTCAGTCGCGGCTATCGAACAGCGCGGCAACGAGATGAAAATCTCAACGCTTAAGCGCTATGTCGAAGCCCTGGGC
GGTACGGTGCGGCTGGATGTCGAGCTGCCGGACGGCCAGCGTTTCGGTTTTACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References