Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 688309..689107 Replicon chromosome
Accession NZ_CP044143
Organism Escherichia coli O157 strain AR-0429

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0V7WHV8
Locus tag F4V41_RS05005 Protein ID WP_001506713.1
Coordinates 688309..688686 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag F4V41_RS05010 Protein ID WP_001280952.1
Coordinates 688733..689107 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F4V41_RS04975 684990..685694 + 705 WP_001241680.1 leucyl/phenylalanyl-tRNA--protein transferase -
F4V41_RS04980 685979..686197 + 219 WP_001040187.1 translation initiation factor IF-1 -
F4V41_RS04990 686688..687530 - 843 WP_001688445.1 DUF4942 domain-containing protein -
F4V41_RS04995 687615..687812 - 198 WP_000839282.1 DUF957 domain-containing protein -
F4V41_RS05000 687824..688312 - 489 WP_001470575.1 hypothetical protein -
F4V41_RS05005 688309..688686 - 378 WP_001506713.1 TA system toxin CbtA family protein Toxin
F4V41_RS05010 688733..689107 - 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F4V41_RS05015 689270..689491 - 222 WP_001220316.1 DUF987 domain-containing protein -
F4V41_RS05020 689560..690036 - 477 WP_001186714.1 RadC family protein -
F4V41_RS05025 690052..690537 - 486 WP_001470565.1 antirestriction protein -
F4V41_RS05030 690629..691447 - 819 WP_001506712.1 DUF945 domain-containing protein -
F4V41_RS05040 691787..692857 - 1071 WP_000102643.1 patatin-like phospholipase family protein -
F4V41_RS05045 692854..693759 - 906 WP_021497799.1 yjcZ-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-118)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14178.26 Da        Isoelectric Point: 7.8045

>T140207 WP_001506713.1 NZ_CP044143:c688686-688309 [Escherichia coli O157]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYITVNNITLGKHPEAKR

Download         Length: 378 bp

>T140207 NZ_CP059043:c288789-288532 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT140207 WP_001280952.1 NZ_CP044143:c689107-688733 [Escherichia coli O157]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT140207 NZ_CP059043:c288520-287975 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0V7WHV8

Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References